Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 325804..326570 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GQX72_RS15230 Protein ID WP_000982260.1
Coordinates 325804..326301 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GQX72_RS15235 Protein ID WP_000246253.1
Coordinates 326298..326570 (-) Length 91 a.a.

Genomic Context

GQX72_RS15175GQX72_RS15180GQX72_RS15200GQX72_RS15205GQX72_RS15210GQX72_RS15220GQX72_RS15225GQX72_RS15240GQX72_RS15250GQX72_RS15265GQX72_RS15270GQX72_RS15275GQX72_RS15280GQX72_RS15285GQX72_RS15290GQX72_RS15295GQX72_RS15190GQX72_RS15195GQX72_RS15230GQX72_RS15235GQX72_RS15255GQX72_RS15260
Location: 321246..321950 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 322108..322446 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 323422..323808 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 323865..323978 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 323927..324208 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 324466..325002 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 325139..325654 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 326963..327088 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 327338..327784 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 328758..329036 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 329288..329494 (207 bp)
Type: Others
Protein ID: Protein_290
Location: 329694..329795 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 329785..330171 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 330366..330617 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 330590..330739 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 330831..331073 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 322600..322917 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 322936..323178 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 325804..326301 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 326298..326570 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 327932..328201 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 328194..328472 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GQX72_RS15175321246..321950+705WP_000087610.1HNH endonuclease-
GQX72_RS15180322108..322446+339WP_000713853.1hypothetical protein-
GQX72_RS15190322600..322917-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
GQX72_RS15195322936..323178-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GQX72_RS15200323422..323808+387WP_001015867.1NUDIX hydrolase-
GQX72_RS15205323865..323978+114WP_001900214.1hypothetical protein-
GQX72_RS15210323927..324208+282WP_001894429.1DUF1289 domain-containing protein-
GQX72_RS15220324466..325002+537WP_000469482.1GNAT family N-acetyltransferase-
GQX72_RS15225325139..325654+516WP_001201509.1lipocalin family protein-
GQX72_RS15230325804..326301-498WP_000982260.1GNAT family N-acetyltransferaseToxin
GQX72_RS15235326298..326570-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
GQX72_RS15240326963..327088+126WP_001905700.1DUF645 family protein-
GQX72_RS15250327338..327784+447WP_000006157.1hypothetical protein-
GQX72_RS15255327932..328201-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
GQX72_RS15260328194..328472-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
GQX72_RS15265328758..329036+279WP_001921601.1DUF3709 domain-containing protein-
GQX72_RS15270329288..329494+207Protein_290DUF3709 domain-containing protein-
GQX72_RS15275329694..329795+102WP_001921603.1hypothetical protein-
GQX72_RS15280329785..330171+387WP_000703163.1VOC family protein-
GQX72_RS15285330366..330617+252WP_001890111.1TIGR03643 family protein-
GQX72_RS15290330590..330739+150WP_071908333.1DUF3265 domain-containing protein-
GQX72_RS15295330831..331073+243WP_000107461.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-305960..411159105199
insideIntegron--311040..41078399743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145393 WP_000982260.1 NZ_CP047060:c326301-325804 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145393 NZ_CP062372:c827356-827168 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145393 WP_000246253.1 NZ_CP047060:c326570-326298 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145393 NZ_CP062372:c827645-827385 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References