145393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 325804..326570 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GQX72_RS15230 Protein ID WP_000982260.1
Coordinates 325804..326301 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GQX72_RS15235 Protein ID WP_000246253.1
Coordinates 326298..326570 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS15175 321246..321950 + 705 WP_000087610.1 HNH endonuclease -
GQX72_RS15180 322108..322446 + 339 WP_000713853.1 hypothetical protein -
GQX72_RS15190 322600..322917 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
GQX72_RS15195 322936..323178 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GQX72_RS15200 323422..323808 + 387 WP_001015867.1 NUDIX hydrolase -
GQX72_RS15205 323865..323978 + 114 WP_001900214.1 hypothetical protein -
GQX72_RS15210 323927..324208 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GQX72_RS15220 324466..325002 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GQX72_RS15225 325139..325654 + 516 WP_001201509.1 lipocalin family protein -
GQX72_RS15230 325804..326301 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
GQX72_RS15235 326298..326570 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
GQX72_RS15240 326963..327088 + 126 WP_001905700.1 DUF645 family protein -
GQX72_RS15250 327338..327784 + 447 WP_000006157.1 hypothetical protein -
GQX72_RS15255 327932..328201 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
GQX72_RS15260 328194..328472 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GQX72_RS15265 328758..329036 + 279 WP_001921601.1 DUF3709 domain-containing protein -
GQX72_RS15270 329288..329494 + 207 Protein_290 DUF3709 domain-containing protein -
GQX72_RS15275 329694..329795 + 102 WP_001921603.1 hypothetical protein -
GQX72_RS15280 329785..330171 + 387 WP_000703163.1 VOC family protein -
GQX72_RS15285 330366..330617 + 252 WP_001890111.1 TIGR03643 family protein -
GQX72_RS15290 330590..330739 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GQX72_RS15295 330831..331073 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305960..411159 105199
inside Integron - - 311040..410783 99743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145393 WP_000982260.1 NZ_CP047060:c326301-325804 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145393 NZ_CP062372:c827356-827168 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145393 WP_000246253.1 NZ_CP047060:c326570-326298 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145393 NZ_CP062372:c827645-827385 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References