Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 340850..341700 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag ASZ79_RS15820 Protein ID WP_000118351.1
Coordinates 341167..341700 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ASZ79_RS15815 Protein ID WP_001909340.1
Coordinates 340850..341170 (+) Length 107 a.a.

Genomic Context

ASZ79_RS15775ASZ79_RS15785ASZ79_RS15790ASZ79_RS20500ASZ79_RS15795ASZ79_RS15800ASZ79_RS20505ASZ79_RS15805ASZ79_RS15815ASZ79_RS15820ASZ79_RS15825ASZ79_RS15830ASZ79_RS15840ASZ79_RS15845ASZ79_RS15850ASZ79_RS15855
Location: 336186..336668 (483 bp)
Type: Others
Protein ID: WP_000422940.1
Location: 337476..337745 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 337739..338260 (522 bp)
Type: Others
Protein ID: WP_000921692.1
Location: 338317..338430 (114 bp)
Type: Others
Protein ID: WP_001894981.1
Location: 338399..339235 (837 bp)
Type: Others
Protein ID: WP_000242986.1
Location: 339400..340038 (639 bp)
Type: Others
Protein ID: WP_000230118.1
Location: 340128..340288 (161 bp)
Type: Others
Protein ID: Protein_308
Location: 340309..340530 (222 bp)
Type: Others
Protein ID: WP_012705854.1
Location: 340850..341170 (321 bp)
Type: Antitoxin
Protein ID: WP_001909340.1
Location: 341167..341700 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 341938..342216 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 342617..342841 (225 bp)
Type: Others
Protein ID: WP_001894423.1
Location: 343579..343968 (390 bp)
Type: Others
Protein ID: WP_000491263.1
Location: 344101..344616 (516 bp)
Type: Others
Protein ID: WP_000090008.1
Location: 344757..345194 (438 bp)
Type: Others
Protein ID: WP_001202554.1
Location: 345355..345702 (348 bp)
Type: Others
Protein ID: WP_000933409.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS15775336186..336668+483WP_000422940.1GNAT family N-acetyltransferase-
ASZ79_RS15785337476..337745+270WP_001114075.1DUF4160 domain-containing protein-
ASZ79_RS15790337739..338260+522WP_000921692.1DUF2442 domain-containing protein-
ASZ79_RS20500338317..338430+114WP_001894981.1hypothetical protein-
ASZ79_RS15795338399..339235+837WP_000242986.1hypothetical protein-
ASZ79_RS15800339400..340038+639WP_000230118.1HD domain-containing protein-
ASZ79_RS20505340128..340288+161Protein_308DUF3709 domain-containing protein-
ASZ79_RS15805340309..340530+222WP_012705854.1DUF3709 domain-containing protein-
ASZ79_RS15815340850..341170+321WP_001909340.1DUF1778 domain-containing proteinAntitoxin
ASZ79_RS15820341167..341700+534WP_000118351.1GNAT family N-acetyltransferaseToxin
ASZ79_RS15825341938..342216+279WP_000280324.1DUF3709 domain-containing protein-
ASZ79_RS15830342617..342841+225WP_001894423.1DUF3709 domain-containing protein-
ASZ79_RS15840343579..343968+390WP_000491263.1VOC family protein-
ASZ79_RS15845344101..344616+516WP_000090008.1hypothetical protein-
ASZ79_RS15850344757..345194+438WP_001202554.1NUDIX pyrophosphatase-
ASZ79_RS15855345355..345702+348WP_000933409.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(22-98)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T58352 WP_000118351.1 NZ_CP013314:341167-341700 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T58352 NZ_CP013314:341167-341700 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11759.53 Da        Isoelectric Point: 4.9309

>AT58352 WP_001909340.1 NZ_CP013314:340850-341170 [Vibrio cholerae]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 321 bp

>AT58352 NZ_CP013314:340850-341170 [Vibrio cholerae]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References