Detailed information of TA system TA058352

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 340850..341700
• Replicon: chromosome
• Accession: NZ_CP013314
• Organism: Vibrio cholerae strain E9120

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KM94
• Locus tag: ASZ79_RS15820
• Protein ID: WP_000118351.1
• Coordinates: 341167..341700 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ASZ79_RS15815
• Protein ID: WP_001909340.1
• Coordinates: 340850..341170 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ79_RS15775	336186..336668	+	483	WP_000422940.1	GNAT family N-acetyltransferase	-
ASZ79_RS15785	337476..337745	+	270	WP_001114075.1	DUF4160 domain-containing protein	-
ASZ79_RS15790	337739..338260	+	522	WP_000921692.1	DUF2442 domain-containing protein	-
ASZ79_RS20500	338317..338430	+	114	WP_001894981.1	hypothetical protein	-
ASZ79_RS15795	338399..339235	+	837	WP_000242986.1	hypothetical protein	-
ASZ79_RS15800	339400..340038	+	639	WP_000230118.1	HD domain-containing protein	-
ASZ79_RS20505	340128..340288	+	161	Protein_308	DUF3709 domain-containing protein	-
ASZ79_RS15805	340309..340530	+	222	WP_012705854.1	DUF3709 domain-containing protein	-
ASZ79_RS15815	340850..341170	+	321	WP_001909340.1	DUF1778 domain-containing protein	Antitoxin
ASZ79_RS15820	341167..341700	+	534	WP_000118351.1	GNAT family N-acetyltransferase	Toxin
ASZ79_RS15825	341938..342216	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ79_RS15830	342617..342841	+	225	WP_001894423.1	DUF3709 domain-containing protein	-
ASZ79_RS15840	343579..343968	+	390	WP_000491263.1	VOC family protein	-
ASZ79_RS15845	344101..344616	+	516	WP_000090008.1	hypothetical protein	-
ASZ79_RS15850	344757..345194	+	438	WP_001202554.1	NUDIX pyrophosphatase	-
ASZ79_RS15855	345355..345702	+	348	WP_000933409.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304700..468464	163764
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.005	inside	Integron	-	-	309780..468088	158308

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (22-98)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20171.46 Da
• Isoelectric Point: 9.1432

>T58352 WP_000118351.1 NZ_CP013314:341167-341700 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T58352 NZ_CP013314:341167-341700 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11759.53 Da
• Isoelectric Point: 4.9309

>AT58352 WP_001909340.1 NZ_CP013314:340850-341170 [Vibrio cholerae]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 321 bp

>AT58352 NZ_CP013314:340850-341170 [Vibrio cholerae]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A

Structures

Toxin

• AlphaFold DB: Q9KM94