Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 513990..514528 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ87_RS17015 Protein ID WP_000802136.1
Coordinates 513990..514289 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ87_RS17020 Protein ID WP_001107719.1
Coordinates 514286..514528 (-) Length 81 a.a.

Genomic Context

ASZ87_RS16965ASZ87_RS16970ASZ87_RS16975ASZ87_RS16980ASZ87_RS16985ASZ87_RS16990ASZ87_RS17005ASZ87_RS17010ASZ87_RS17025ASZ87_RS17030ASZ87_RS17040ASZ87_RS17045ASZ87_RS17050ASZ87_RS17055ASZ87_RS17060ASZ87_RS17015ASZ87_RS17020
Location: 509925..510107 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 510307..510780 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 510795..510887 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 510929..511555 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 511678..512376 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 512386..512496 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 513074..513253 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 513467..513862 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 514757..515335 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 515357..515449 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 515873..516556 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 516770..517036 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 517191..517790 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 518071..519006 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 518972..519112 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 513990..514289 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 514286..514528 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS16965509925..510107+183WP_000923182.1DUF645 family protein-
ASZ87_RS16970510307..510780+474WP_001161076.1GrpB family protein-
ASZ87_RS16975510795..510887+93WP_014378730.1DUF3265 domain-containing protein-
ASZ87_RS16980510929..511555+627WP_000365424.1LysE family translocator-
ASZ87_RS16985511678..512376+699WP_001890502.1hypothetical protein-
ASZ87_RS16990512386..512496+111WP_079857360.1DUF3265 domain-containing protein-
ASZ87_RS17005513074..513253+180WP_001883058.1DUF645 family protein-
ASZ87_RS17010513467..513862+396WP_000870857.1DUF3465 domain-containing protein-
ASZ87_RS17015513990..514289-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ87_RS17020514286..514528-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
ASZ87_RS17025514757..515335+579WP_000110120.1hypothetical protein-
ASZ87_RS17030515357..515449+93WP_014164112.1DUF3265 domain-containing protein-
ASZ87_RS17040515873..516556+684WP_000877436.1hypothetical protein-
ASZ87_RS17045516770..517036+267WP_000937852.1hypothetical protein-
ASZ87_RS17050517191..517790+600WP_000429495.1hypothetical protein-
ASZ87_RS17055518071..519006+936WP_000051985.1restriction endonuclease-
ASZ87_RS17060518972..519112+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58311 WP_000802136.1 NZ_CP013310:c514289-513990 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58311 NZ_CP013310:c514289-513990 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58311 WP_001107719.1 NZ_CP013310:c514528-514286 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58311 NZ_CP013310:c514528-514286 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References