Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 452258..453213 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag ASZ81_RS17030 Protein ID WP_000118351.1
Coordinates 452680..453213 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag ASZ81_RS17025 Protein ID WP_001882332.1
Coordinates 452258..452683 (+) Length 142 a.a.

Genomic Context

ASZ81_RS16975ASZ81_RS16980ASZ81_RS16985ASZ81_RS16995ASZ81_RS17010ASZ81_RS17015ASZ81_RS17020ASZ81_RS17025ASZ81_RS17030ASZ81_RS17035ASZ81_RS17040ASZ81_RS17045ASZ81_RS17055ASZ81_RS17060ASZ81_RS17065ASZ81_RS17070ASZ81_RS17080ASZ81_RS17000ASZ81_RS17005
Location: 447788..448039 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 448029..448316 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 448444..448899 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 449221..449373 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 450572..451240 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 451392..451679 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 451820..452191 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 452258..452683 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 452680..453213 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 453415..453672 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 453660..453962 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 454196..455113 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 455270..455659 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 455795..456004 (210 bp)
Type: Others
Protein ID: Protein_514
Location: 456123..456560 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 456624..456842 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 457017..457889 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 449575..450072 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 450069..450341 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS16975447788..448039+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ81_RS16980448029..448316+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ81_RS16985448444..448899+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ81_RS16995449221..449373+153WP_001884520.1DUF645 family protein-
ASZ81_RS17000449575..450072-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ81_RS17005450069..450341-273WP_000246253.1DUF1778 domain-containing protein-
ASZ81_RS17010450572..451240+669WP_000043871.1hypothetical protein-
ASZ81_RS17015451392..451679+288WP_000426470.1hypothetical protein-
ASZ81_RS17020451820..452191+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ81_RS17025452258..452683+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
ASZ81_RS17030452680..453213+534WP_000118351.1GNAT family N-acetyltransferaseToxin
ASZ81_RS17035453415..453672+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ81_RS17040453660..453962+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ81_RS17045454196..455113+918WP_000186333.1alpha/beta hydrolase-
ASZ81_RS17055455270..455659+390WP_001081302.1hypothetical protein-
ASZ81_RS17060455795..456004+210Protein_514GNAT family N-acetyltransferase-
ASZ81_RS17065456123..456560+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ81_RS17070456624..456842+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ81_RS17080457017..457889+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353
flankIS/Tn--456123..456560437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T58276 WP_000118351.1 NZ_CP013306:452680-453213 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T58276 NZ_CP013306:452680-453213 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT58276 WP_001882332.1 NZ_CP013306:452258-452683 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT58276 NZ_CP013306:452258-452683 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References