Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 369837..370452 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag J9265_RS15585 Protein ID WP_001162670.1
Coordinates 369837..370124 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J9265_RS15590 Protein ID WP_001232701.1
Coordinates 370135..370452 (+) Length 106 a.a.

Genomic Context

J9265_RS19080J9265_RS19085J9265_RS15560J9265_RS15565J9265_RS19090J9265_RS15570J9265_RS19095J9265_RS15575J9265_RS15580J9265_RS19100J9265_RS15585J9265_RS15590J9265_RS15595J9265_RS19105J9265_RS15600J9265_RS19110J9265_RS15610J9265_RS15615J9265_RS15620J9265_RS15625J9265_RS15630J9265_RS15550J9265_RS15555
Location: 365180..365355 (176 bp)
Type: Others
Protein ID: Protein_366
Location: 365416..365568 (153 bp)
Type: Others
Protein ID: Protein_367
Location: 366582..367091 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 367148..367801 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 367890..368099 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 368111..368329 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 368518..368711 (194 bp)
Type: Others
Protein ID: Protein_374
Location: 368732..368965 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 369390..369570 (181 bp)
Type: Others
Protein ID: Protein_376
Location: 369683..369796 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 369837..370124 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 370135..370452 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 370449..370559 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 370598..370708 (111 bp)
Type: Others
Protein ID: Protein_381
Location: 370736..370861 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 370824..370940 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 371139..371879 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 372084..372914 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 373064..373453 (390 bp)
Type: Others
Protein ID: WP_001081310.1
Location: 373984..374775 (792 bp)
Type: Others
Protein ID: WP_012706050.1
Location: 374905..375360 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 365762..366079 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 366098..366340 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J9265_RS19080365180..365355+176Protein_366acetyltransferase-
J9265_RS19085365416..365568+153Protein_367DUF645 family protein-
J9265_RS15550 (J9265_15550)365762..366079-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
J9265_RS15555 (J9265_15555)366098..366340-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
J9265_RS15560 (J9265_15560)366582..367091+510WP_000405987.1GNAT family N-acetyltransferase-
J9265_RS15565 (J9265_15565)367148..367801+654WP_000226874.1hypothetical protein-
J9265_RS19090367890..368099+210WP_001900246.1DUF3709 domain-containing protein-
J9265_RS15570 (J9265_15570)368111..368329+219WP_001917086.1DUF3709 domain-containing protein-
J9265_RS19095368518..368711+194Protein_374hypothetical protein-
J9265_RS15575 (J9265_15575)368732..368965+234WP_032482776.1DUF3709 domain-containing protein-
J9265_RS15580 (J9265_15580)369390..369570+181Protein_376DUF645 family protein-
J9265_RS19100369683..369796+114WP_001894955.1hypothetical protein-
J9265_RS15585 (J9265_15585)369837..370124+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
J9265_RS15590 (J9265_15590)370135..370452+318WP_001232701.1HigA family addiction module antitoxinAntitoxin
J9265_RS15595 (J9265_15595)370449..370559+111WP_134814058.1DUF3265 domain-containing protein-
J9265_RS19105370598..370708+111Protein_381acetyltransferase-
J9265_RS15600 (J9265_15600)370736..370861+126WP_001944767.1DUF645 family protein-
J9265_RS19110370824..370940+117WP_001889170.1hypothetical protein-
J9265_RS15610 (J9265_15610)371139..371879+741WP_000469836.1PhzF family phenazine biosynthesis protein-
J9265_RS15615 (J9265_15615)372084..372914+831WP_000056616.1abortive infection family protein-
J9265_RS15620 (J9265_15620)373064..373453+390WP_001081310.1hypothetical protein-
J9265_RS15625 (J9265_15625)373984..374775+792WP_012706050.1hypothetical protein-
J9265_RS15630 (J9265_15630)374905..375360+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T198985 WP_001162670.1 NZ_CP072848:369837-370124 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T198985 NZ_CP097080:c49900-49430 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT198985 WP_001232701.1 NZ_CP072848:370135-370452 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT198985 NZ_CP097080:c50340-49897 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References