Detailed information of TA system TA198985

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 369837..370452
• Replicon: chromosome
• Accession: NZ_CP072848
• Organism: Vibrio cholerae strain A1552

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q9KMG5
• Locus tag: J9265_RS15585
• Protein ID: WP_001162670.1
• Coordinates: 369837..370124 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: J9265_RS15590
• Protein ID: WP_001232701.1
• Coordinates: 370135..370452 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9265_RS19080	365180..365355	+	176	Protein_366	acetyltransferase	-
J9265_RS19085	365416..365568	+	153	Protein_367	DUF645 family protein	-
J9265_RS15550 (J9265_15550)	365762..366079	-	318	WP_001180243.1	type II toxin-antitoxin system RelE/ParE family toxin	-
J9265_RS15555 (J9265_15555)	366098..366340	-	243	WP_000557292.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
J9265_RS15560 (J9265_15560)	366582..367091	+	510	WP_000405987.1	GNAT family N-acetyltransferase	-
J9265_RS15565 (J9265_15565)	367148..367801	+	654	WP_000226874.1	hypothetical protein	-
J9265_RS19090	367890..368099	+	210	WP_001900246.1	DUF3709 domain-containing protein	-
J9265_RS15570 (J9265_15570)	368111..368329	+	219	WP_001917086.1	DUF3709 domain-containing protein	-
J9265_RS19095	368518..368711	+	194	Protein_374	hypothetical protein	-
J9265_RS15575 (J9265_15575)	368732..368965	+	234	WP_032482776.1	DUF3709 domain-containing protein	-
J9265_RS15580 (J9265_15580)	369390..369570	+	181	Protein_376	DUF645 family protein	-
J9265_RS19100	369683..369796	+	114	WP_001894955.1	hypothetical protein	-
J9265_RS15585 (J9265_15585)	369837..370124	+	288	WP_001162670.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J9265_RS15590 (J9265_15590)	370135..370452	+	318	WP_001232701.1	HigA family addiction module antitoxin	Antitoxin
J9265_RS15595 (J9265_15595)	370449..370559	+	111	WP_134814058.1	DUF3265 domain-containing protein	-
J9265_RS19105	370598..370708	+	111	Protein_381	acetyltransferase	-
J9265_RS15600 (J9265_15600)	370736..370861	+	126	WP_001944767.1	DUF645 family protein	-
J9265_RS19110	370824..370940	+	117	WP_001889170.1	hypothetical protein	-
J9265_RS15610 (J9265_15610)	371139..371879	+	741	WP_000469836.1	PhzF family phenazine biosynthesis protein	-
J9265_RS15615 (J9265_15615)	372084..372914	+	831	WP_000056616.1	abortive infection family protein	-
J9265_RS15620 (J9265_15620)	373064..373453	+	390	WP_001081310.1	hypothetical protein	-
J9265_RS15625 (J9265_15625)	373984..374775	+	792	WP_012706050.1	hypothetical protein	-
J9265_RS15630 (J9265_15630)	374905..375360	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	306914..436175	129261
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0	inside	Integron	-	-	311994..435799	123805

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-69)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11349.95 Da
• Isoelectric Point: 6.7187

>T198985 WP_001162670.1 NZ_CP072848:369837-370124 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Nucleotide

• Length: 288 bp

>T198985 NZ_CP097080:c49900-49430 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11705.63 Da
• Isoelectric Point: 10.4711

>AT198985 WP_001232701.1 NZ_CP072848:370135-370452 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Nucleotide

• Length: 318 bp

>AT198985 NZ_CP097080:c50340-49897 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A0F2HI36