89002

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 429122..429526 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag VCA1552_RS16890 Protein ID WP_001114075.1
Coordinates 429257..429526 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag VCA1552_RS16885 Protein ID WP_099607150.1
Coordinates 429122..429226 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCA1552_RS16850 424623..425540 + 918 WP_000186333.1 alpha/beta hydrolase -
VCA1552_RS16855 425697..426086 + 390 WP_001081302.1 hypothetical protein -
VCA1552_RS16860 426222..426431 + 210 Protein_463 GNAT family N-acetyltransferase -
VCA1552_RS16865 426550..426987 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
VCA1552_RS16870 427051..427269 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
VCA1552_RS16875 427444..428316 + 873 WP_000254716.1 DUF3800 domain-containing protein -
VCA1552_RS16880 428466..429065 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
VCA1552_RS16885 429122..429226 + 105 WP_099607150.1 acetyltransferase Antitoxin
VCA1552_RS16890 429257..429526 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
VCA1552_RS16895 429520..430041 + 522 WP_000921691.1 DUF2442 domain-containing protein -
VCA1552_RS16900 430340..430465 + 126 WP_001905700.1 DUF645 family protein -
VCA1552_RS16910 430716..431111 + 396 WP_001000867.1 hypothetical protein -
VCA1552_RS16915 431250..431528 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
VCA1552_RS16920 431525..431809 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
VCA1552_RS16925 432003..432518 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
VCA1552_RS16935 432702..433115 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304717..433978 129261
inside Integron - - 309797..433602 123805
flank IS/Tn - - 426550..426987 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T89002 WP_001114075.1 NZ_CP024868:429257-429526 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T89002 NZ_CP024868:429257-429526 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT89002 WP_099607150.1 NZ_CP024868:429122-429226 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT89002 NZ_CP024868:429122-429226 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References