Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 399707..400235 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag J9265_RS15840 Protein ID WP_000221352.1
Coordinates 399707..399997 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag J9265_RS15845 Protein ID WP_000213183.1
Coordinates 399987..400235 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9265_RS15800 (J9265_15800) 395264..395389 + 126 WP_001944767.1 DUF645 family protein -
J9265_RS19155 395352..395468 + 117 WP_001889170.1 hypothetical protein -
J9265_RS15810 (J9265_15810) 395656..396660 + 1005 WP_000964925.1 LD-carboxypeptidase -
J9265_RS15815 (J9265_15815) 396813..397259 + 447 WP_000128977.1 hypothetical protein -
J9265_RS15820 (J9265_15820) 397379..398308 + 930 WP_000335802.1 hypothetical protein -
J9265_RS15825 (J9265_15825) 398305..398415 + 111 WP_071917832.1 DUF3265 domain-containing protein -
J9265_RS15830 (J9265_15830) 398443..398919 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
J9265_RS15835 (J9265_15835) 399110..399571 + 462 WP_001911752.1 lipocalin family protein -
J9265_RS15840 (J9265_15840) 399707..399997 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9265_RS15845 (J9265_15845) 399987..400235 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J9265_RS15850 (J9265_15850) 400806..401459 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
J9265_RS15855 (J9265_15855) 401731..402156 + 426 WP_000415748.1 hypothetical protein -
J9265_RS15860 (J9265_15860) 402364..402759 + 396 WP_000649527.1 DUF3465 domain-containing protein -
J9265_RS15865 (J9265_15865) 402910..403440 + 531 WP_000415563.1 hypothetical protein -
J9265_RS15870 (J9265_15870) 403578..404078 + 501 WP_000789723.1 hypothetical protein -
J9265_RS15875 (J9265_15875) 404234..404632 + 399 WP_001882293.1 hypothetical protein -
J9265_RS15880 (J9265_15880) 404732..405196 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T198986 WP_000221352.1 NZ_CP072848:c399997-399707 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T198986 NZ_CP097080:113020-113502 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACAAAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT198986 WP_000213183.1 NZ_CP072848:c400235-399987 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT198986 NZ_CP097080:112751-113029 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References