Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 399707..400235 | Replicon | chromosome |
Accession | NZ_CP072848 | ||
Organism | Vibrio cholerae strain A1552 |
Toxin (Protein)
Gene name | relE | Uniprot ID | H9L4R3 |
Locus tag | J9265_RS15840 | Protein ID | WP_000221352.1 |
Coordinates | 399707..399997 (-) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | H9L4T4 |
Locus tag | J9265_RS15845 | Protein ID | WP_000213183.1 |
Coordinates | 399987..400235 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J9265_RS15800 (J9265_15800) | 395264..395389 | + | 126 | WP_001944767.1 | DUF645 family protein | - |
J9265_RS19155 | 395352..395468 | + | 117 | WP_001889170.1 | hypothetical protein | - |
J9265_RS15810 (J9265_15810) | 395656..396660 | + | 1005 | WP_000964925.1 | LD-carboxypeptidase | - |
J9265_RS15815 (J9265_15815) | 396813..397259 | + | 447 | WP_000128977.1 | hypothetical protein | - |
J9265_RS15820 (J9265_15820) | 397379..398308 | + | 930 | WP_000335802.1 | hypothetical protein | - |
J9265_RS15825 (J9265_15825) | 398305..398415 | + | 111 | WP_071917832.1 | DUF3265 domain-containing protein | - |
J9265_RS15830 (J9265_15830) | 398443..398919 | + | 477 | WP_001047180.1 | GNAT family N-acetyltransferase | - |
J9265_RS15835 (J9265_15835) | 399110..399571 | + | 462 | WP_001911752.1 | lipocalin family protein | - |
J9265_RS15840 (J9265_15840) | 399707..399997 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
J9265_RS15845 (J9265_15845) | 399987..400235 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
J9265_RS15850 (J9265_15850) | 400806..401459 | + | 654 | WP_000036957.1 | site-specific DNA-methyltransferase | - |
J9265_RS15855 (J9265_15855) | 401731..402156 | + | 426 | WP_000415748.1 | hypothetical protein | - |
J9265_RS15860 (J9265_15860) | 402364..402759 | + | 396 | WP_000649527.1 | DUF3465 domain-containing protein | - |
J9265_RS15865 (J9265_15865) | 402910..403440 | + | 531 | WP_000415563.1 | hypothetical protein | - |
J9265_RS15870 (J9265_15870) | 403578..404078 | + | 501 | WP_000789723.1 | hypothetical protein | - |
J9265_RS15875 (J9265_15875) | 404234..404632 | + | 399 | WP_001882293.1 | hypothetical protein | - |
J9265_RS15880 (J9265_15880) | 404732..405196 | - | 465 | WP_000140244.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 306914..436175 | 129261 | |
inside | Integron | - | - | 311994..435799 | 123805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.23 Da Isoelectric Point: 10.4678
>T198986 WP_000221352.1 NZ_CP072848:c399997-399707 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T198986 NZ_CP097080:113020-113502 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACAAAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACAAAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8937.28 Da Isoelectric Point: 4.1079
>AT198986 WP_000213183.1 NZ_CP072848:c400235-399987 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT198986 NZ_CP097080:112751-113029 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | H9L4R3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A366A3W8 |