Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 492328..492875 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag IT766_RS16330 Protein ID WP_000229317.1
Coordinates 492573..492875 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag IT766_RS16325 Protein ID WP_000861987.1
Coordinates 492328..492585 (+) Length 86 a.a.

Genomic Context

IT766_RS16280IT766_RS16285IT766_RS16300IT766_RS16305IT766_RS16310IT766_RS16315IT766_RS16320IT766_RS16325IT766_RS16330IT766_RS16335IT766_RS16340IT766_RS16345IT766_RS16350IT766_RS16355IT766_RS16360IT766_RS16365IT766_RS16370IT766_RS16290IT766_RS16295
Location: 487357..487812 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 488134..488286 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 489485..490153 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 490305..490592 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 490733..491104 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 491171..491596 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 491593..492126 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 492328..492585 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 492573..492875 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 493109..494026 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 494183..494572 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 494708..494917 (210 bp)
Type: Others
Protein ID: Protein_519
Location: 495036..495473 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 495537..495755 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 495930..496802 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 496952..497551 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 497608..497712 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 488488..488985 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 488982..489254 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IT766_RS16280487357..487812+456WP_001245327.1GNAT family N-acetyltransferase-
IT766_RS16285488134..488286+153WP_001884520.1DUF645 family protein-
IT766_RS16290488488..488985-498WP_000982260.1GNAT family N-acetyltransferase-
IT766_RS16295488982..489254-273WP_000246253.1DUF1778 domain-containing protein-
IT766_RS16300489485..490153+669WP_000043871.1hypothetical protein-
IT766_RS16305490305..490592+288WP_000426470.1hypothetical protein-
IT766_RS16310490733..491104+372WP_001164080.1nucleotide pyrophosphohydrolase-
IT766_RS16315491171..491596+426WP_001882332.1DUF1778 domain-containing protein-
IT766_RS16320491593..492126+534WP_000118351.1GNAT family N-acetyltransferase-
IT766_RS16325492328..492585+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
IT766_RS16330492573..492875+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IT766_RS16335493109..494026+918WP_000186333.1alpha/beta hydrolase-
IT766_RS16340494183..494572+390WP_001081302.1hypothetical protein-
IT766_RS16345494708..494917+210Protein_519GNAT family N-acetyltransferase-
IT766_RS16350495036..495473+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
IT766_RS16355495537..495755+219WP_071908318.1GNAT family N-acetyltransferase-
IT766_RS16360495930..496802+873WP_000254716.1DUF3800 domain-containing protein-
IT766_RS16365496952..497551+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
IT766_RS16370497608..497712+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-373204..502464129260
insideIntegron--378284..502088123804
flankIS/Tn--495036..495473437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T180879 WP_000229317.1 NZ_CP064351:492573-492875 [Vibrio cholerae C6706]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T180879 NZ_CP085767:3644153-3644674 [Enterobacter hormaechei]
GTGGCAAATCTCACGATCGAAATGTTATCAGAGGGAACCGATTACGATTTCGGCGATTTCGATTGTGGTGAACCCTCGCT
AAATGCCTTCCTTACCGAGCACCTGGTACGTCAGCACGGCGGGCGTATTTTACGCGGCTACCTGCTTAAAGAACGCGACC
ATCCGCGTGTCCTGGGCTATTACACACTCTCGGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCAAAGACTCAGCAGCGC
CGCATCCCATACAGCAACGTCCCCAGCGTGACGCTGGGGCGTCTGGCTGTCCATAAAGAACTACAGGGAAACGAGTGGGG
AACAACGCTTGTCACACACGCTATGCGCGTTGTTTATCTGGCGTCGCAGGCTGTTGGCGTCCACGGAATTTTTGTGGATG
CGCTTAACGAACGGGCCAAACGATTTTATCTGAAGCTGGGGTTTATCCCGCTGGCAGGTGAAAACAGCAGTTCGCTGTTC
TTCCCCACGCAATCTATCGAACGACTGTTTGAGCAGGCGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT180879 WP_000861987.1 NZ_CP064351:492328-492585 [Vibrio cholerae C6706]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT180879 NZ_CP085767:3643877-3644146 [Enterobacter hormaechei]
ATGCCAGCACTCAAAAAACAGCGTATCGATCTTCGCCTGTCGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACCAACCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCCGAAGTCATCGAACAGCATCGGCGTC
TCGTATTAAACGAAGCCTCATGGAATGCCGTTATGGATGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References