Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 369827..370442 Replicon chromosome
Accession NZ_CP047296
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag GTF72_RS15590 Protein ID WP_001162670.1
Coordinates 369827..370114 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GTF72_RS15595 Protein ID WP_001232701.1
Coordinates 370125..370442 (+) Length 106 a.a.

Genomic Context

GTF72_RS15550GTF72_RS15565GTF72_RS15570GTF72_RS15575GTF72_RS15580GTF72_RS15585GTF72_RS15590GTF72_RS15595GTF72_RS15600GTF72_RS15605GTF72_RS15610GTF72_RS15615GTF72_RS15620GTF72_RS15625GTF72_RS15630GTF72_RS15635GTF72_RS15555GTF72_RS15560
Location: 365463..365558 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 366572..367081 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 367138..367791 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 368101..368319 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 368722..368955 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 369380..369560 (181 bp)
Type: Others
Protein ID: Protein_365
Location: 369827..370114 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 370125..370442 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 370439..370549 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 370726..370851 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 370867..370905 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 371129..371869 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 372074..372904 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 372961..373443 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 373890..374765 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 374895..375350 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 365752..366069 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 366088..366330 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF72_RS15550365463..365558+96WP_001907607.1DUF645 family protein-
GTF72_RS15555365752..366069-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF72_RS15560366088..366330-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF72_RS15565366572..367081+510WP_000405987.1GNAT family N-acetyltransferase-
GTF72_RS15570367138..367791+654WP_000226874.1hypothetical protein-
GTF72_RS15575368101..368319+219WP_001917086.1DUF3709 domain-containing protein-
GTF72_RS15580368722..368955+234WP_032482776.1DUF3709 domain-containing protein-
GTF72_RS15585369380..369560+181Protein_365DUF645 family protein-
GTF72_RS15590369827..370114+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF72_RS15595370125..370442+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
GTF72_RS15600370439..370549+111WP_134814058.1DUF3265 domain-containing protein-
GTF72_RS15605370726..370851+126WP_001944767.1DUF645 family protein-
GTF72_RS15610370867..370905+39WP_106019119.1hypothetical protein-
GTF72_RS15615371129..371869+741WP_000469836.1PhzF family phenazine biosynthesis protein-
GTF72_RS15620372074..372904+831WP_000056616.1abortive infection family protein-
GTF72_RS15625372961..373443+483WP_001895003.1hypothetical protein-
GTF72_RS15630373890..374765+876WP_000259044.1hypothetical protein-
GTF72_RS15635374895..375350+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306905..436165129260
insideIntegron--311985..435789123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T145810 WP_001162670.1 NZ_CP047296:369827-370114 [Vibrio cholerae C6706]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T145810 NZ_CP062700:1080203-1080538 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT145810 WP_001232701.1 NZ_CP047296:370125-370442 [Vibrio cholerae C6706]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT145810 NZ_CP062700:1079955-1080203 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References