Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 395373..395901 | Replicon | chromosome |
Accession | NZ_CP047302 | ||
Organism | Vibrio cholerae O1 biovar El Tor strain DRC-193A |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0X1KZS6 |
Locus tag | GTF75_RS15985 | Protein ID | WP_000221354.1 |
Coordinates | 395614..395901 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0X1KZS8 |
Locus tag | GTF75_RS15980 | Protein ID | WP_001250179.1 |
Coordinates | 395373..395624 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GTF75_RS15935 | 390641..390955 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | - |
GTF75_RS15940 | 391092..391526 | + | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
GTF75_RS15945 | 391694..391849 | + | 156 | WP_000751734.1 | hypothetical protein | - |
GTF75_RS15950 | 391974..392954 | - | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
GTF75_RS15955 | 393022..393294 | + | 273 | Protein_410 | CatB-related O-acetyltransferase | - |
GTF75_RS15960 | 393465..394157 | + | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
GTF75_RS15965 | 394157..394558 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
GTF75_RS15970 | 394528..394671 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
GTF75_RS15975 | 394746..395159 | + | 414 | WP_000049417.1 | VOC family protein | - |
GTF75_RS15980 | 395373..395624 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
GTF75_RS15985 | 395614..395901 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GTF75_RS15990 | 396029..396484 | + | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
GTF75_RS15995 | 396806..396958 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
GTF75_RS16000 | 397160..397657 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
GTF75_RS16005 | 397654..397926 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
GTF75_RS16010 | 398157..398825 | + | 669 | WP_000043871.1 | hypothetical protein | - |
GTF75_RS16015 | 398977..399264 | + | 288 | WP_000426470.1 | hypothetical protein | - |
GTF75_RS16020 | 399405..399776 | + | 372 | WP_001164080.1 | nucleotide pyrophosphohydrolase | - |
GTF75_RS16025 | 399843..400268 | + | 426 | WP_001882332.1 | DUF1778 domain-containing protein | - |
GTF75_RS16030 | 400265..400798 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 305935..411136 | 105201 | |
inside | Integron | - | - | 311015..410760 | 99745 | ||
flank | IS/Tn | - | - | 391974..392954 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10991.96 Da Isoelectric Point: 10.4934
>T145875 WP_000221354.1 NZ_CP047302:395614-395901 [Vibrio cholerae O1 biovar El Tor]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
Download Length: 288 bp
>T145875 NZ_CP062705:3114572-3114679 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9136.29 Da Isoelectric Point: 4.0197
>AT145875 WP_001250179.1 NZ_CP047302:395373-395624 [Vibrio cholerae O1 biovar El Tor]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL
Download Length: 252 bp
>AT145875 NZ_CP062705:c3114524-3114465 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0X1KZS6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0X1KZS8 |