180871

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 432051..432629 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag IT766_RS15800 Protein ID WP_001180243.1
Coordinates 432051..432368 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag IT766_RS15805 Protein ID WP_000557292.1
Coordinates 432387..432629 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT766_RS15755 427242..427637 + 396 WP_000046952.1 hypothetical protein -
IT766_RS15760 427940..428121 + 182 Protein_402 DUF645 family protein -
IT766_RS15765 428298..428693 + 396 WP_000046953.1 hypothetical protein -
IT766_RS15770 428837..429373 + 537 WP_000644491.1 nucleotidyltransferase family protein -
IT766_RS15775 429670..429849 + 180 WP_001883039.1 DUF645 family protein -
IT766_RS15780 430045..430470 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
IT766_RS15785 430619..430966 + 348 WP_000933409.1 hypothetical protein -
IT766_RS15790 431113..431406 + 294 WP_125460920.1 hypothetical protein -
IT766_RS15795 431762..431857 + 96 WP_001907607.1 DUF645 family protein -
IT766_RS15800 432051..432368 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IT766_RS15805 432387..432629 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IT766_RS15810 432871..433380 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
IT766_RS15815 433437..434090 + 654 WP_000226874.1 hypothetical protein -
IT766_RS15820 434400..434618 + 219 WP_001917086.1 DUF3709 domain-containing protein -
IT766_RS15825 435021..435254 + 234 WP_032482776.1 DUF3709 domain-containing protein -
IT766_RS15830 435679..435859 + 181 Protein_416 DUF645 family protein -
IT766_RS15835 436126..436413 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
IT766_RS15840 436424..436741 + 318 WP_001232701.1 HigA family addiction module antidote protein -
IT766_RS15845 436738..436848 + 111 WP_134814058.1 DUF3265 domain-containing protein -
IT766_RS15850 437025..437150 + 126 WP_001944767.1 DUF645 family protein -
IT766_RS15855 437166..437204 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 373204..502464 129260
inside Integron - - 378284..502088 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T180871 WP_001180243.1 NZ_CP064351:c432368-432051 [Vibrio cholerae C6706]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T180871 NZ_CP085767:2064894-2065145 [Enterobacter hormaechei]
ATGCGTGTTATTAGTTACAGTGAAGCCCGACAAAACCTGTCGGCAACCATGGTTCAGACGACGGAAGACCGCGCGCCGGT
GCTTATTACGCGCCAGAACGGTGAATCTTGTGTTCTGATGTCGCTGGAAGAGTACAACTCGCTTGAAGAAACCGCATACC
TGATGCGCTCCCCGGCAAACGCAAAACGTCTGATGAACTCTATCGAGAGCTTGAAATCTGGTAGCGGGAAGGAAAGGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT180871 WP_000557292.1 NZ_CP064351:c432629-432387 [Vibrio cholerae C6706]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT180871 NZ_CP085767:2065142-2065396 [Enterobacter hormaechei]
GTGAAGATCACATGGTCTGAAGAGGCATGGGAAGACTACCTCTATTGGCAGGAGACCGATAAGCGCATGGTGAGGAAAAT
CAATGAGCTTATCAAAATCTCCTGTCGCACTCCGTTTGAGGGGATCGGCAAGCCAGAGCCATTAAAACATAACCTGGCTG
GCTTCTGGTCTCGCCGAATCACCTCTGAGCATCGCATGGTCTATGCCATCACAGAAGAAGCGATCCTCATAGCTGCGTGC
CGATATCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References