Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 435596..436229 Replicon chromosome
Accession NZ_OW443148
Organism Vibrio cholerae strain CNRVC190243 isolate YE-NCPHL-19014-PI

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag OC617_RS16175 Protein ID WP_000843587.1
Coordinates 435596..435928 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OC617_RS16180 Protein ID WP_000071008.1
Coordinates 435915..436229 (+) Length 105 a.a.

Genomic Context

OC617_RS16115OC617_RS16120OC617_RS16125OC617_RS16130OC617_RS16135OC617_RS16140OC617_RS16145OC617_RS16150OC617_RS16155OC617_RS16160OC617_RS16165OC617_RS16170OC617_RS16175OC617_RS16180OC617_RS16185OC617_RS16190OC617_RS16200OC617_RS16205OC617_RS16210OC617_RS16215OC617_RS16220OC617_RS16225OC617_RS16230OC617_RS16235OC617_RS16195
Location: 430831..430896 (66 bp)
Type: Others
Protein ID: Protein_445
Location: 431037..431240 (204 bp)
Type: Others
Protein ID: WP_001911745.1
Location: 431497..431694 (198 bp)
Type: Others
Protein ID: WP_001894451.1
Location: 432054..432323 (270 bp)
Type: Others
Protein ID: WP_001198131.1
Location: 432659..432812 (154 bp)
Type: Others
Protein ID: Protein_449
Location: 433021..433407 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 433492..433851 (360 bp)
Type: Others
Protein ID: WP_226979446.1
Location: 434022..434399 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 434456..434570 (115 bp)
Type: Others
Protein ID: Protein_453
Location: 434579..434800 (222 bp)
Type: Others
Protein ID: WP_032468461.1
Location: 434966..435079 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 435028..435255 (228 bp)
Type: Others
Protein ID: WP_073426587.1
Location: 435596..435928 (333 bp)
Type: Toxin
Protein ID: WP_000843587.1
Location: 435915..436229 (315 bp)
Type: Antitoxin
Protein ID: WP_000071008.1
Location: 436366..436800 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 436968..437123 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 438296..438602 (307 bp)
Type: Others
Protein ID: Protein_462
Location: 438739..439137 (399 bp)
Type: Others
Protein ID: Protein_463
Location: 439261..439431 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 439431..439832 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 439835..439945 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 440020..440433 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 440647..440898 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 440888..441175 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 437248..438228 (981 bp)
Type: Others
Protein ID: WP_000019370.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OC617_RS16115430831..430896+66Protein_445acetyltransferase-
OC617_RS16120431037..431240+204WP_001911745.1hypothetical protein-
OC617_RS16125431497..431694+198WP_001894451.1DUF3709 domain-containing protein-
OC617_RS16130 (CNRVC190243H_03167)432054..432323+270WP_001198131.1hypothetical protein-
OC617_RS16135432659..432812+154Protein_449DUF645 family protein-
OC617_RS16140 (CNRVC190243H_03168)433021..433407+387WP_000703163.1VOC family protein-
OC617_RS16145 (CNRVC190243H_03169)433492..433851+360WP_226979446.1pullulanase-
OC617_RS16150 (CNRVC190243H_03170)434022..434399+378WP_000411109.1hypothetical protein-
OC617_RS16155434456..434570+115Protein_453acetyltransferase-
OC617_RS16160 (CNRVC190243H_03171)434579..434800+222WP_032468461.1DUF1289 domain-containing protein-
OC617_RS16165434966..435079+114WP_001889158.1hypothetical protein-
OC617_RS16170435028..435255+228WP_073426587.1DUF1289 domain-containing protein-
OC617_RS16175 (CNRVC190243H_03172)435596..435928+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxinToxin
OC617_RS16180 (CNRVC190243H_03173)435915..436229+315WP_000071008.1DNA-binding transcriptional regulatorAntitoxin
OC617_RS16185 (CNRVC190243H_03174)436366..436800+435WP_000256036.1GNAT family N-acetyltransferase-
OC617_RS16190 (CNRVC190243H_03175)436968..437123+156WP_000751734.1hypothetical protein-
OC617_RS16195 (CNRVC190243H_03176)437248..438228-981WP_000019370.1IS5-like element ISVch5 family transposase-
OC617_RS16200 (CNRVC190243H_03177)438296..438602+307Protein_462CatB-related O-acetyltransferase-
OC617_RS16205438739..439137+399Protein_463GNAT family N-acetyltransferase-
OC617_RS16210439261..439431+171WP_001080654.1hypothetical protein-
OC617_RS16215 (CNRVC190243H_03179)439431..439832+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
OC617_RS16220439835..439945+111WP_082798255.1DUF3265 domain-containing protein-
OC617_RS16225 (CNRVC190243H_03180)440020..440433+414WP_000049417.1VOC family protein-
OC617_RS16230 (CNRVC190243H_03181)440647..440898+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
OC617_RS16235 (CNRVC190243H_03182)440888..441175+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-349905..456410106505
insideIntegroncatB9-354985..456034101049
flankIS/Tn--437248..438228980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T295395 WP_000843587.1 NZ_OW443148:435596-435928 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT295395 WP_000071008.1 NZ_OW443148:435915-436229 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5JA9
PDB8A0X
PDB5MJE
PDB5JA8
PDB5JAA

Antitoxin

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Source
ID
Structure
No matching records found

References