295395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 435596..436229 Replicon chromosome
Accession NZ_OW443148
Organism Vibrio cholerae strain CNRVC190243 isolate YE-NCPHL-19014-PI

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag OC617_RS16175 Protein ID WP_000843587.1
Coordinates 435596..435928 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OC617_RS16180 Protein ID WP_000071008.1
Coordinates 435915..436229 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OC617_RS16115 430831..430896 + 66 Protein_445 acetyltransferase -
OC617_RS16120 431037..431240 + 204 WP_001911745.1 hypothetical protein -
OC617_RS16125 431497..431694 + 198 WP_001894451.1 DUF3709 domain-containing protein -
OC617_RS16130 (CNRVC190243H_03167) 432054..432323 + 270 WP_001198131.1 hypothetical protein -
OC617_RS16135 432659..432812 + 154 Protein_449 DUF645 family protein -
OC617_RS16140 (CNRVC190243H_03168) 433021..433407 + 387 WP_000703163.1 VOC family protein -
OC617_RS16145 (CNRVC190243H_03169) 433492..433851 + 360 WP_226979446.1 pullulanase -
OC617_RS16150 (CNRVC190243H_03170) 434022..434399 + 378 WP_000411109.1 hypothetical protein -
OC617_RS16155 434456..434570 + 115 Protein_453 acetyltransferase -
OC617_RS16160 (CNRVC190243H_03171) 434579..434800 + 222 WP_032468461.1 DUF1289 domain-containing protein -
OC617_RS16165 434966..435079 + 114 WP_001889158.1 hypothetical protein -
OC617_RS16170 435028..435255 + 228 WP_073426587.1 DUF1289 domain-containing protein -
OC617_RS16175 (CNRVC190243H_03172) 435596..435928 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OC617_RS16180 (CNRVC190243H_03173) 435915..436229 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
OC617_RS16185 (CNRVC190243H_03174) 436366..436800 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
OC617_RS16190 (CNRVC190243H_03175) 436968..437123 + 156 WP_000751734.1 hypothetical protein -
OC617_RS16195 (CNRVC190243H_03176) 437248..438228 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
OC617_RS16200 (CNRVC190243H_03177) 438296..438602 + 307 Protein_462 CatB-related O-acetyltransferase -
OC617_RS16205 438739..439137 + 399 Protein_463 GNAT family N-acetyltransferase -
OC617_RS16210 439261..439431 + 171 WP_001080654.1 hypothetical protein -
OC617_RS16215 (CNRVC190243H_03179) 439431..439832 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
OC617_RS16220 439835..439945 + 111 WP_082798255.1 DUF3265 domain-containing protein -
OC617_RS16225 (CNRVC190243H_03180) 440020..440433 + 414 WP_000049417.1 VOC family protein -
OC617_RS16230 (CNRVC190243H_03181) 440647..440898 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
OC617_RS16235 (CNRVC190243H_03182) 440888..441175 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 349905..456410 106505
inside Integron catB9 - 354985..456034 101049
flank IS/Tn - - 437248..438228 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T295395 WP_000843587.1 NZ_OW443148:435596-435928 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT295395 WP_000071008.1 NZ_OW443148:435915-436229 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References