Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 388599..389554 Replicon chromosome
Accession NZ_CP012666
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name - Uniprot ID Q9KM94
Locus tag AN947_RS02245 Protein ID WP_000118351.1
Coordinates 389021..389554 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag AN947_RS20785 Protein ID WP_001882332.1
Coordinates 388599..389024 (+) Length 142 a.a.

Genomic Context

AN947_RS02180AN947_RS02185AN947_RS02190AN947_RS02200AN947_RS02225AN947_RS02230AN947_RS02235AN947_RS20785AN947_RS02245AN947_RS02255AN947_RS02260AN947_RS02270AN947_RS02280AN947_RS02285AN947_RS02290AN947_RS02295AN947_RS02300AN947_RS02210AN947_RS02215
Location: 384129..384380 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 384370..384657 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 384785..385240 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 385562..385714 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 386913..387581 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 387733..388020 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 388161..388532 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 388599..389024 (426 bp)
Type: Antitoxin
Protein ID: WP_001882332.1
Location: 389021..389554 (534 bp)
Type: Toxin
Protein ID: WP_000118351.1
Location: 389756..390013 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 390001..390303 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 390537..391454 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 391611..392000 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 392136..392345 (210 bp)
Type: Others
Protein ID: Protein_407
Location: 392464..392901 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 392965..393183 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 393358..394230 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 385916..386413 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 386410..386682 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AN947_RS02180384129..384380+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
AN947_RS02185384370..384657+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
AN947_RS02190384785..385240+456WP_001245327.1GNAT family N-acetyltransferase-
AN947_RS02200385562..385714+153WP_001884520.1DUF645 family protein-
AN947_RS02210385916..386413-498WP_000982260.1GNAT family N-acetyltransferase-
AN947_RS02215386410..386682-273WP_000246253.1DUF1778 domain-containing protein-
AN947_RS02225386913..387581+669WP_000043871.1hypothetical protein-
AN947_RS02230387733..388020+288WP_000426470.1hypothetical protein-
AN947_RS02235388161..388532+372WP_001164080.1nucleotide pyrophosphohydrolase-
AN947_RS20785388599..389024+426WP_001882332.1DUF1778 domain-containing proteinAntitoxin
AN947_RS02245389021..389554+534WP_000118351.1GNAT family N-acetyltransferaseToxin
AN947_RS02255389756..390013+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
AN947_RS02260390001..390303+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
AN947_RS02270390537..391454+918WP_000186333.1alpha/beta hydrolase-
AN947_RS02280391611..392000+390WP_001081302.1hypothetical protein-
AN947_RS02285392136..392345+210Protein_407GNAT family N-acetyltransferase-
AN947_RS02290392464..392901+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
AN947_RS02295392965..393183+219WP_071908318.1GNAT family N-acetyltransferase-
AN947_RS02300393358..394230+873WP_000254716.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791
flankIS/Tn--392464..392901437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(57-133)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20171.46 Da        Isoelectric Point: 9.1432

>T56921 WP_000118351.1 NZ_CP012666:389021-389554 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T56921 NZ_CP012666:389021-389554 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATACGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15714.41 Da        Isoelectric Point: 7.6659

>AT56921 WP_001882332.1 NZ_CP012666:388599-389024 [Vibrio cholerae]
MLCLSLVVMRCQPLRRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLK
SLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 426 bp

>AT56921 NZ_CP012666:388599-389024 [Vibrio cholerae]
TTGTTGTGTTTGAGTTTAGTGGTCATGCGTTGTCAGCCCCTTAGACGGGCGTTATATTCTCCCTCGCCCCGTAAACTTTC
CGTACGAATTGAATGTGCTTTAAGTTTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGG
CAACGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCTGAAAAGGCATCGGCTTTACTTGGTTTAAAA
AGTCTCACTGAATATGTGGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAA
AGACAGTGTTTTTGACGAGTTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAAT
TTACAGAGAAGAGCGGTATCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM94

Antitoxin

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Source
ID
Structure
No matching records found

References