26148

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 349446..349984 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag O3Y_RS15650 Protein ID WP_000802136.1
Coordinates 349446..349745 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag O3Y_RS15655 Protein ID WP_001107719.1
Coordinates 349742..349984 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Y_RS15615 345381..345563 + 183 WP_000923182.1 DUF645 family protein -
O3Y_RS15620 345763..346236 + 474 WP_001161076.1 GrpB family protein -
O3Y_RS19680 346251..346343 + 93 WP_014378730.1 DUF3265 domain-containing protein -
O3Y_RS15625 346385..347011 + 627 WP_000365424.1 LysE family translocator -
O3Y_RS15630 347134..347832 + 699 WP_001890502.1 hypothetical protein -
O3Y_RS19685 347842..347952 + 111 WP_079857360.1 DUF3265 domain-containing protein -
O3Y_RS15640 348530..348709 + 180 WP_001883058.1 DUF645 family protein -
O3Y_RS15645 348923..349318 + 396 WP_000870857.1 DUF3465 domain-containing protein -
O3Y_RS15650 349446..349745 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O3Y_RS15655 349742..349984 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
O3Y_RS19160 350213..350791 + 579 WP_000110120.1 hypothetical protein -
O3Y_RS19695 350813..350905 + 93 WP_014164112.1 DUF3265 domain-containing protein -
O3Y_RS15670 351329..352012 + 684 WP_000877436.1 hypothetical protein -
O3Y_RS15675 352226..352492 + 267 WP_000937852.1 hypothetical protein -
O3Y_RS15680 352647..353246 + 600 WP_000429495.1 hypothetical protein -
O3Y_RS15685 353527..354462 + 936 WP_000051985.1 restriction endonuclease -
O3Y_RS19705 354428..354568 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304637..435582 130945
inside Integron - - 309717..435206 125489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T26148 WP_000802136.1 NC_016945:c349745-349446 [Vibrio cholerae IEC224]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T26148 NC_016945:c349745-349446 [Vibrio cholerae IEC224]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT26148 WP_001107719.1 NC_016945:c349984-349742 [Vibrio cholerae IEC224]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT26148 NC_016945:c349984-349742 [Vibrio cholerae IEC224]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References