Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 876838..877453 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag LZM82_RS17625 Protein ID WP_001162670.1
Coordinates 877166..877453 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZM82_RS17620 Protein ID WP_001232701.1
Coordinates 876838..877155 (-) Length 106 a.a.

Genomic Context

LZM82_RS17670LZM82_RS17675LZM82_RS17570LZM82_RS17575LZM82_RS17580LZM82_RS17585LZM82_RS17590LZM82_RS17595LZM82_RS17600LZM82_RS17605LZM82_RS17610LZM82_RS17615LZM82_RS17620LZM82_RS17625LZM82_RS17630LZM82_RS17635LZM82_RS17640LZM82_RS17645LZM82_RS17650LZM82_RS17655LZM82_RS17660LZM82_RS17665LZM82_RS17680LZM82_RS17685
Location: 880950..881192 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 881211..881528 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 872247..872708 (462 bp)
Type: Others
Protein ID: WP_001911578.1
Location: 872899..873375 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 873403..873513 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 873510..874439 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 874559..875005 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 875158..876162 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 876350..876466 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 876429..876554 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 876582..876692 (111 bp)
Type: Others
Protein ID: Protein_790
Location: 876731..876841 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 876838..877155 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 877166..877453 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 877494..877607 (114 bp)
Type: Others
Protein ID: WP_001894955.1
Location: 877720..877900 (181 bp)
Type: Others
Protein ID: Protein_795
Location: 878325..878558 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 878579..878772 (194 bp)
Type: Others
Protein ID: Protein_797
Location: 878961..879179 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 879191..879400 (210 bp)
Type: Others
Protein ID: WP_001900246.1
Location: 879489..880142 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 880199..880708 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 881722..881874 (153 bp)
Type: Others
Protein ID: Protein_804
Location: 881935..882110 (176 bp)
Type: Others
Protein ID: Protein_805
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZM82_RS17570 (LZM82_17570)872247..872708-462WP_001911578.1lipocalin family protein-
LZM82_RS17575 (LZM82_17575)872899..873375-477WP_001047180.1GNAT family N-acetyltransferase-
LZM82_RS17580 (LZM82_17580)873403..873513-111WP_071917832.1DUF3265 domain-containing protein-
LZM82_RS17585 (LZM82_17585)873510..874439-930WP_000335802.1hypothetical protein-
LZM82_RS17590 (LZM82_17590)874559..875005-447WP_000128977.1hypothetical protein-
LZM82_RS17595 (LZM82_17595)875158..876162-1005WP_000964925.1LD-carboxypeptidase-
LZM82_RS17600 (LZM82_17600)876350..876466-117WP_001889170.1hypothetical protein-
LZM82_RS17605 (LZM82_17605)876429..876554-126WP_001944767.1DUF645 family protein-
LZM82_RS17610 (LZM82_17610)876582..876692-111Protein_790acetyltransferase-
LZM82_RS17615 (LZM82_17615)876731..876841-111WP_134814058.1DUF3265 domain-containing protein-
LZM82_RS17620 (LZM82_17620)876838..877155-318WP_001232701.1HigA family addiction module antitoxinAntitoxin
LZM82_RS17625 (LZM82_17625)877166..877453-288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LZM82_RS17630 (LZM82_17630)877494..877607-114WP_001894955.1hypothetical protein-
LZM82_RS17635 (LZM82_17635)877720..877900-181Protein_795DUF645 family protein-
LZM82_RS17640 (LZM82_17640)878325..878558-234WP_032482776.1DUF3709 domain-containing protein-
LZM82_RS17645 (LZM82_17645)878579..878772-194Protein_797hypothetical protein-
LZM82_RS17650 (LZM82_17650)878961..879179-219WP_001917086.1DUF3709 domain-containing protein-
LZM82_RS17655 (LZM82_17655)879191..879400-210WP_001900246.1DUF3709 domain-containing protein-
LZM82_RS17660 (LZM82_17660)879489..880142-654WP_000226874.1hypothetical protein-
LZM82_RS17665 (LZM82_17665)880199..880708-510WP_000405987.1GNAT family N-acetyltransferase-
LZM82_RS17670 (LZM82_17670)880950..881192+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
LZM82_RS17675 (LZM82_17675)881211..881528+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
LZM82_RS17680 (LZM82_17680)881722..881874-153Protein_804DUF645 family protein-
LZM82_RS17685 (LZM82_17685)881935..882110-176Protein_805acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-835643..943910108267
insideIntegron--836019..937068101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T230644 WP_001162670.1 NZ_CP090400:c877453-877166 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T230644 NZ_CP125223:c2389019-2388837 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATAGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACGT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT230644 WP_001232701.1 NZ_CP090400:c877155-876838 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT230644 NZ_CP125223:c2388744-2388340 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References