Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 369749..370515 Replicon chromosome
Accession NZ_OW443148
Organism Vibrio cholerae strain CNRVC190243 isolate YE-NCPHL-19014-PI

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag OC617_RS15510 Protein ID WP_000982260.1
Coordinates 369749..370246 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag OC617_RS15515 Protein ID WP_000246253.1
Coordinates 370243..370515 (-) Length 91 a.a.

Genomic Context

OC617_RS15460OC617_RS15465OC617_RS15480OC617_RS15485OC617_RS15490OC617_RS15495OC617_RS15500OC617_RS15505OC617_RS15520OC617_RS15525OC617_RS15530OC617_RS15545OC617_RS15550OC617_RS15555OC617_RS15560OC617_RS15565OC617_RS15470OC617_RS15475OC617_RS15510OC617_RS15515OC617_RS15535OC617_RS15540
Location: 365191..365895 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 366053..366391 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 367367..367753 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 367810..367923 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 367932..368153 (222 bp)
Type: Others
Protein ID: WP_032467793.1
Location: 368411..368947 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 369138..369599 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 369664..369732 (69 bp)
Type: Others
Protein ID: Protein_323
Location: 370908..371033 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 371283..371729 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 371792..373003 (1212 bp)
Type: Others
Protein ID: WP_001122813.1
Location: 373781..373898 (118 bp)
Type: Others
Protein ID: Protein_331
Location: 374016..374294 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 374654..374752 (99 bp)
Type: Others
Protein ID: WP_223225486.1
Location: 374952..375053 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 375043..375429 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 366545..366862 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 366881..367123 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 369749..370246 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 370243..370515 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 373190..373459 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 373452..373730 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OC617_RS15460 (CNRVC190243H_03080)365191..365895+705WP_000087610.1HNH endonuclease-
OC617_RS15465 (CNRVC190243H_03081)366053..366391+339WP_000713853.1hypothetical protein-
OC617_RS15470 (CNRVC190243H_03082)366545..366862-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
OC617_RS15475 (CNRVC190243H_03083)366881..367123-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
OC617_RS15480 (CNRVC190243H_03084)367367..367753+387WP_001015867.1NUDIX hydrolase-
OC617_RS15485367810..367923+114WP_001900214.1hypothetical protein-
OC617_RS15490 (CNRVC190243H_03085)367932..368153+222WP_032467793.1DUF1289 domain-containing protein-
OC617_RS15495 (CNRVC190243H_03086)368411..368947+537WP_000469482.1GNAT family protein-
OC617_RS15500 (CNRVC190243H_03087)369138..369599+462WP_001903091.1lipocalin family protein-
OC617_RS15505369664..369732+69Protein_323acetyltransferase-
OC617_RS15510 (CNRVC190243H_03088)369749..370246-498WP_000982260.1GNAT family N-acetyltransferaseToxin
OC617_RS15515 (CNRVC190243H_03089)370243..370515-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
OC617_RS15520370908..371033+126WP_001900195.1DUF645 family protein-
OC617_RS15525 (CNRVC190243H_03090)371283..371729+447WP_000006157.1hypothetical protein-
OC617_RS15530 (CNRVC190243H_03091)371792..373003+1212WP_001122813.1IS256 family transposase-
OC617_RS15535 (CNRVC190243H_03092)373190..373459-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
OC617_RS15540 (CNRVC190243H_03093)373452..373730-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
OC617_RS15545373781..373898+118Protein_331DUF3265 domain-containing protein-
OC617_RS15550374016..374294+279WP_001921601.1DUF3709 domain-containing protein-
OC617_RS15555374654..374752+99WP_223225486.1DUF3709 domain-containing protein-
OC617_RS15560374952..375053+102WP_001921603.1hypothetical protein-
OC617_RS15565 (CNRVC190243H_03094)375043..375429+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-349905..456410106505
insideIntegroncatB9-354985..456034101049
-flankIS/Tn--371792..3730031211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T295387 WP_000982260.1 NZ_OW443148:c370246-369749 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT295387 WP_000246253.1 NZ_OW443148:c370515-370243 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References