Detailed information of TA system TA058318

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 582683..583449
• Replicon: chromosome
• Accession: NZ_CP013310
• Organism: Vibrio cholerae strain E1162

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9K2P7
• Locus tag: ASZ87_RS17700
• Protein ID: WP_000982260.1
• Coordinates: 582683..583180 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9K2J6
• Locus tag: ASZ87_RS17705
• Protein ID: WP_000246253.1
• Coordinates: 583177..583449 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ87_RS17650	578545..578851	+	307	Protein_610	CatB-related O-acetyltransferase	-
ASZ87_RS17655	578988..579680	+	693	WP_001047169.1	GNAT family N-acetyltransferase	-
ASZ87_RS17660	579680..580081	+	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	-
ASZ87_RS20820	580051..580194	+	144	WP_071908341.1	DUF3265 domain-containing protein	-
ASZ87_RS17670	580269..580682	+	414	WP_000049417.1	VOC family protein	-
ASZ87_RS17675	580896..581147	+	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ASZ87_RS17680	581137..581424	+	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ASZ87_RS17685	581552..582007	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-
ASZ87_RS17695	582329..582481	+	153	WP_001884520.1	DUF645 family protein	-
ASZ87_RS17700	582683..583180	-	498	WP_000982260.1	GNAT family N-acetyltransferase	Toxin
ASZ87_RS17705	583177..583449	-	273	WP_000246253.1	DUF1778 domain-containing protein	Antitoxin
ASZ87_RS17710	583680..584348	+	669	WP_000043871.1	hypothetical protein	-
ASZ87_RS17715	584500..584787	+	288	WP_000426470.1	hypothetical protein	-
ASZ87_RS17720	584928..585299	+	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
ASZ87_RS17725	585366..585791	+	426	WP_001882332.1	DUF1778 domain-containing protein	-
ASZ87_RS17730	585788..586321	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
ASZ87_RS17735	586523..586780	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ASZ87_RS17740	586768..587070	+	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ASZ87_RS17745	587304..588221	+	918	WP_000186333.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	435534..596659	161125
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.005	inside	Integron	-	-	440614..596283	155669
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000174, TA000175, TA000176, TA010030 416601..417581 0	flank	IS/Tn	-	-	577497..578477	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-86)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18527.18 Da
• Isoelectric Point: 8.7753

>T58318 WP_000982260.1 NZ_CP013310:c583180-582683 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Nucleotide

• Length: 498 bp

>T58318 NZ_CP013310:c583180-582683 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9683.22 Da
• Isoelectric Point: 6.2988

>AT58318 WP_000246253.1 NZ_CP013310:c583449-583177 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Nucleotide

• Length: 273 bp

>AT58318 NZ_CP013310:c583449-583177 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Structures

Toxin

• AlphaFold DB: A0A0Q0KGB1

Antitoxin

• AlphaFold DB: A0A0F2IC79