Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 582683..583449 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ87_RS17700 Protein ID WP_000982260.1
Coordinates 582683..583180 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ87_RS17705 Protein ID WP_000246253.1
Coordinates 583177..583449 (-) Length 91 a.a.

Genomic Context

ASZ87_RS17650ASZ87_RS17655ASZ87_RS17660ASZ87_RS20820ASZ87_RS17670ASZ87_RS17675ASZ87_RS17680ASZ87_RS17685ASZ87_RS17695ASZ87_RS17710ASZ87_RS17715ASZ87_RS17720ASZ87_RS17725ASZ87_RS17730ASZ87_RS17735ASZ87_RS17740ASZ87_RS17745ASZ87_RS17700ASZ87_RS17705
Location: 578545..578851 (307 bp)
Type: Others
Protein ID: Protein_610
Location: 578988..579680 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 579680..580081 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 580051..580194 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 580269..580682 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 580896..581147 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 581137..581424 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 581552..582007 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 582329..582481 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 583680..584348 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 584500..584787 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 584928..585299 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 585366..585791 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 585788..586321 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 586523..586780 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 586768..587070 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 587304..588221 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 582683..583180 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 583177..583449 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS17650578545..578851+307Protein_610CatB-related O-acetyltransferase-
ASZ87_RS17655578988..579680+693WP_001047169.1GNAT family N-acetyltransferase-
ASZ87_RS17660579680..580081+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ASZ87_RS20820580051..580194+144WP_071908341.1DUF3265 domain-containing protein-
ASZ87_RS17670580269..580682+414WP_000049417.1VOC family protein-
ASZ87_RS17675580896..581147+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ87_RS17680581137..581424+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ87_RS17685581552..582007+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ87_RS17695582329..582481+153WP_001884520.1DUF645 family protein-
ASZ87_RS17700582683..583180-498WP_000982260.1GNAT family N-acetyltransferaseToxin
ASZ87_RS17705583177..583449-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
ASZ87_RS17710583680..584348+669WP_000043871.1hypothetical protein-
ASZ87_RS17715584500..584787+288WP_000426470.1hypothetical protein-
ASZ87_RS17720584928..585299+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ87_RS17725585366..585791+426WP_001882332.1DUF1778 domain-containing protein-
ASZ87_RS17730585788..586321+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ87_RS17735586523..586780+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ87_RS17740586768..587070+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ87_RS17745587304..588221+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669
flankIS/Tn--577497..578477980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58318 WP_000982260.1 NZ_CP013310:c583180-582683 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58318 NZ_CP013310:c583180-582683 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58318 WP_000246253.1 NZ_CP013310:c583449-583177 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58318 NZ_CP013310:c583449-583177 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References