Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 251218..251833 Replicon chromosome
Accession NZ_LT992493
Organism Vibrio cholerae strain 4295STDY6534248

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag DG169_RS15810 Protein ID WP_001162670.1
Coordinates 251218..251505 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DG169_RS15815 Protein ID WP_001232701.1
Coordinates 251516..251833 (+) Length 106 a.a.

Genomic Context

DG169_RS19830DG169_RS15780DG169_RS15785DG169_RS15790DG169_RS15795DG169_RS15800DG169_RS15810DG169_RS15815DG169_RS19835DG169_RS19840DG169_RS19845DG169_RS15840DG169_RS15845DG169_RS15850DG169_RS15855DG169_RS15860DG169_RS15865DG169_RS15770DG169_RS15775
Location: 246854..246949 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 247963..248472 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 248529..249182 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 249492..249710 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 250113..250346 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 250771..250951 (181 bp)
Type: Others
Protein ID: Protein_262
Location: 251218..251505 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 251516..251833 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 251830..251940 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 252117..252242 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 252258..252296 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 252509..253513 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 253666..254112 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 254232..255161 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 255158..255268 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 255296..255772 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 255909..256424 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 247143..247460 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 247479..247721 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG169_RS19830246854..246949+96WP_001907607.1DUF645 family protein-
DG169_RS15770247143..247460-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
DG169_RS15775247479..247721-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG169_RS15780247963..248472+510WP_000405987.1GNAT family N-acetyltransferase-
DG169_RS15785248529..249182+654WP_000226874.1hypothetical protein-
DG169_RS15790249492..249710+219WP_001917086.1DUF3709 domain-containing protein-
DG169_RS15795250113..250346+234WP_032482776.1DUF3709 domain-containing protein-
DG169_RS15800250771..250951+181Protein_262DUF645 family protein-
DG169_RS15810251218..251505+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DG169_RS15815251516..251833+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
DG169_RS19835251830..251940+111WP_134814058.1DUF3265 domain-containing protein-
DG169_RS19840252117..252242+126WP_001944767.1DUF645 family protein-
DG169_RS19845252258..252296+39WP_106019119.1hypothetical protein-
DG169_RS15840252509..253513+1005WP_000964925.1LD-carboxypeptidase-
DG169_RS15845253666..254112+447WP_000128977.1hypothetical protein-
DG169_RS15850254232..255161+930WP_000335802.1hypothetical protein-
DG169_RS15855255158..255268+111WP_071917832.1DUF3265 domain-containing protein-
DG169_RS15860255296..255772+477WP_001047180.1GNAT family N-acetyltransferase-
DG169_RS15865255909..256424+516WP_001201528.1lipocalin family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-197768..29303295264
insideIntegroncatB9-202848..29265689808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T294412 WP_001162670.1 NZ_LT992493:251218-251505 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT294412 WP_001232701.1 NZ_LT992493:251516-251833 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References