95375

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 47682..48260 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag C4E16_RS14380 Protein ID WP_001180243.1
Coordinates 47682..47999 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag C4E16_RS14385 Protein ID WP_000557292.1
Coordinates 48018..48260 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4E16_RS14340 43206..43388 + 183 WP_000923340.1 DUF645 family protein -
C4E16_RS14345 43742..43924 + 183 WP_000923153.1 DUF645 family protein -
C4E16_RS14355 44119..44796 + 678 WP_000254617.1 HNH endonuclease -
C4E16_RS14360 44958..46166 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
C4E16_RS14365 46328..47032 + 705 WP_000087610.1 HNH endonuclease -
C4E16_RS14370 47190..47528 + 339 WP_000713853.1 hypothetical protein -
C4E16_RS14380 47682..47999 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4E16_RS14385 48018..48260 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C4E16_RS14390 48504..48890 + 387 WP_001015867.1 NUDIX hydrolase -
C4E16_RS14395 48947..49060 + 114 WP_001900214.1 hypothetical protein -
C4E16_RS14400 49009..49290 + 282 WP_001894429.1 DUF1289 domain-containing protein -
C4E16_RS14415 49548..50084 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
C4E16_RS14420 50221..50736 + 516 WP_001201509.1 lipocalin family protein -
C4E16_RS14425 50886..51383 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
C4E16_RS14430 51380..51652 - 273 WP_000246253.1 DUF1778 domain-containing protein -
C4E16_RS14435 52045..52170 + 126 WP_001900195.1 DUF645 family protein -
C4E16_RS19415 52186..52224 + 39 WP_106019118.1 hypothetical protein -
C4E16_RS14445 52420..52866 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31043..136234 105191
inside Integron - - 36123..135858 99735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T95375 WP_001180243.1 NZ_CP026648:c47999-47682 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T95375 NZ_CP026648:c47999-47682 [Vibrio cholerae O1 biovar El Tor]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT95375 WP_000557292.1 NZ_CP026648:c48260-48018 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT95375 NZ_CP026648:c48260-48018 [Vibrio cholerae O1 biovar El Tor]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References