Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 47682..48260 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag C4E16_RS14380 Protein ID WP_001180243.1
Coordinates 47682..47999 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag C4E16_RS14385 Protein ID WP_000557292.1
Coordinates 48018..48260 (-) Length 81 a.a.

Genomic Context

C4E16_RS14340C4E16_RS14345C4E16_RS14355C4E16_RS14360C4E16_RS14365C4E16_RS14370C4E16_RS14390C4E16_RS14395C4E16_RS14400C4E16_RS14415C4E16_RS14420C4E16_RS14435C4E16_RS19415C4E16_RS14445C4E16_RS14380C4E16_RS14385C4E16_RS14425C4E16_RS14430
Location: 43206..43388 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 43742..43924 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 44119..44796 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 44958..46166 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 46328..47032 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 47190..47528 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 48504..48890 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 48947..49060 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 49009..49290 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 49548..50084 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 50221..50736 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 52045..52170 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 52186..52224 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 52420..52866 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 47682..47999 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 48018..48260 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 50886..51383 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 51380..51652 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4E16_RS1434043206..43388+183WP_000923340.1DUF645 family protein-
C4E16_RS1434543742..43924+183WP_000923153.1DUF645 family protein-
C4E16_RS1435544119..44796+678WP_000254617.1HNH endonuclease-
C4E16_RS1436044958..46166+1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
C4E16_RS1436546328..47032+705WP_000087610.1HNH endonuclease-
C4E16_RS1437047190..47528+339WP_000713853.1hypothetical protein-
C4E16_RS1438047682..47999-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C4E16_RS1438548018..48260-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
C4E16_RS1439048504..48890+387WP_001015867.1NUDIX hydrolase-
C4E16_RS1439548947..49060+114WP_001900214.1hypothetical protein-
C4E16_RS1440049009..49290+282WP_001894429.1DUF1289 domain-containing protein-
C4E16_RS1441549548..50084+537WP_000469482.1GNAT family N-acetyltransferase-
C4E16_RS1442050221..50736+516WP_001201509.1lipocalin family protein-
C4E16_RS1442550886..51383-498WP_000982260.1GNAT family N-acetyltransferase-
C4E16_RS1443051380..51652-273WP_000246253.1DUF1778 domain-containing protein-
C4E16_RS1443552045..52170+126WP_001900195.1DUF645 family protein-
C4E16_RS1941552186..52224+39WP_106019118.1hypothetical protein-
C4E16_RS1444552420..52866+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31043..136234105191
insideIntegron--36123..13585899735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T95375 WP_001180243.1 NZ_CP026648:c47999-47682 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T95375 NZ_CP026648:c47999-47682 [Vibrio cholerae O1 biovar El Tor]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT95375 WP_000557292.1 NZ_CP026648:c48260-48018 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT95375 NZ_CP026648:c48260-48018 [Vibrio cholerae O1 biovar El Tor]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References