198987

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 415361..415994 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag J9265_RS15970 Protein ID WP_000843587.1
Coordinates 415361..415693 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J9265_RS15975 Protein ID WP_000071008.1
Coordinates 415680..415994 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9265_RS19255 410596..410661 + 66 Protein_454 acetyltransferase -
J9265_RS15915 (J9265_15915) 410802..411005 + 204 WP_001911745.1 hypothetical protein -
J9265_RS15920 (J9265_15920) 411262..411459 + 198 WP_001894451.1 DUF3709 domain-containing protein -
J9265_RS15925 (J9265_15925) 411819..412088 + 270 WP_001198131.1 hypothetical protein -
J9265_RS15930 (J9265_15930) 412424..412577 + 154 Protein_458 DUF645 family protein -
J9265_RS15935 (J9265_15935) 412786..413172 + 387 WP_000703163.1 VOC family protein -
J9265_RS15940 (J9265_15940) 413257..413616 + 360 WP_226979446.1 pullulanase -
J9265_RS15945 (J9265_15945) 413787..414164 + 378 WP_000411109.1 hypothetical protein -
J9265_RS15950 (J9265_15950) 414221..414335 + 115 Protein_462 acetyltransferase -
J9265_RS15955 (J9265_15955) 414344..414565 + 222 WP_032468461.1 DUF1289 domain-containing protein -
J9265_RS15960 (J9265_15960) 414731..414844 + 114 WP_001889158.1 hypothetical protein -
J9265_RS15965 (J9265_15965) 414793..415020 + 228 WP_001894457.1 DUF1289 domain-containing protein -
J9265_RS15970 (J9265_15970) 415361..415693 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9265_RS15975 (J9265_15975) 415680..415994 + 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
J9265_RS15980 (J9265_15980) 416131..416565 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
J9265_RS15985 (J9265_15985) 416733..416888 + 156 WP_000751734.1 hypothetical protein -
J9265_RS15990 (J9265_15990) 417013..417993 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
J9265_RS15995 (J9265_15995) 418061..418367 + 307 Protein_471 CatB-related O-acetyltransferase -
J9265_RS19165 418504..418902 + 399 Protein_472 GNAT family N-acetyltransferase -
J9265_RS19170 419026..419196 + 171 WP_001080654.1 hypothetical protein -
J9265_RS16005 (J9265_16005) 419196..419597 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
J9265_RS16010 (J9265_16010) 419600..419710 + 111 WP_082798255.1 DUF3265 domain-containing protein -
J9265_RS16015 (J9265_16015) 419785..420198 + 414 WP_000049417.1 VOC family protein -
J9265_RS16020 (J9265_16020) 420412..420663 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J9265_RS16025 (J9265_16025) 420653..420940 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805
flank IS/Tn - - 417013..417993 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T198987 WP_000843587.1 NZ_CP072848:415361-415693 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T198987 NZ_CP097080:156521-156964 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT198987 WP_000071008.1 NZ_CP072848:415680-415994 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT198987 NZ_CP097080:156294-156524 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References