Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | dhiT-phd/- |
Location | 431306..431710 | Replicon | chromosome |
Accession | NZ_CP047298 | ||
Organism | Vibrio cholerae O1 biovar El Tor strain C6709 |
Toxin (Protein)
Gene name | dhiT | Uniprot ID | A0A086SLD6 |
Locus tag | GTF73_RS16170 | Protein ID | WP_001114075.1 |
Coordinates | 431441..431710 (+) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | - |
Locus tag | GTF73_RS16165 | Protein ID | WP_099607150.1 |
Coordinates | 431306..431410 (+) | Length | 35 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GTF73_RS16130 | 426807..427724 | + | 918 | WP_000186333.1 | alpha/beta hydrolase | - |
GTF73_RS16135 | 427881..428270 | + | 390 | WP_001081302.1 | hypothetical protein | - |
GTF73_RS16140 | 428406..428615 | + | 210 | Protein_471 | GNAT family N-acetyltransferase | - |
GTF73_RS16145 | 428734..429171 | + | 438 | WP_000503169.1 | IS200/IS605-like element IS1004 family transposase | - |
GTF73_RS16150 | 429235..429453 | + | 219 | WP_071908318.1 | GNAT family N-acetyltransferase | - |
GTF73_RS16155 | 429628..430500 | + | 873 | WP_000254716.1 | DUF3800 domain-containing protein | - |
GTF73_RS16160 | 430650..431249 | + | 600 | WP_001891245.1 | glutathione S-transferase N-terminal domain-containing protein | - |
GTF73_RS16165 | 431306..431410 | + | 105 | WP_099607150.1 | acetyltransferase | Antitoxin |
GTF73_RS16170 | 431441..431710 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | Toxin |
GTF73_RS16175 | 431704..432225 | + | 522 | WP_000921691.1 | DUF2442 domain-containing protein | - |
GTF73_RS16180 | 432524..432649 | + | 126 | WP_001905700.1 | DUF645 family protein | - |
GTF73_RS16185 | 432900..433295 | + | 396 | WP_001000867.1 | hypothetical protein | - |
GTF73_RS16190 | 433434..433712 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
GTF73_RS16195 | 433709..433993 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
GTF73_RS16200 | 434187..434702 | + | 516 | WP_000343779.1 | GNAT family N-acetyltransferase | - |
GTF73_RS16205 | 434759..434854 | + | 96 | WP_099607151.1 | acetyltransferase | - |
GTF73_RS16210 | 434886..435299 | + | 414 | WP_000049420.1 | VOC family protein | - |
GTF73_RS16215 | 435306..435438 | - | 133 | Protein_486 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 306901..436162 | 129261 | |
inside | Integron | - | - | 311981..435786 | 123805 | ||
flank | IS/Tn | - | - | 428734..429171 | 437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10310.94 Da Isoelectric Point: 6.6303
>T145839 WP_001114075.1 NZ_CP047298:431441-431710 [Vibrio cholerae O1 biovar El Tor]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC
Download Length: 270 bp
>T145839 NZ_CP062702:1087173-1087508 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 35 a.a. Molecular weight: 3991.79 Da Isoelectric Point: 9.2853
>AT145839 WP_099607150.1 NZ_CP047298:431306-431410 [Vibrio cholerae O1 biovar El Tor]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL
Download Length: 105 bp
>AT145839 NZ_CP062702:1086925-1087173 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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