145839

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) dhiT-phd/-
Location 431306..431710 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag GTF73_RS16170 Protein ID WP_001114075.1
Coordinates 431441..431710 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GTF73_RS16165 Protein ID WP_099607150.1
Coordinates 431306..431410 (+) Length 35 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS16130 426807..427724 + 918 WP_000186333.1 alpha/beta hydrolase -
GTF73_RS16135 427881..428270 + 390 WP_001081302.1 hypothetical protein -
GTF73_RS16140 428406..428615 + 210 Protein_471 GNAT family N-acetyltransferase -
GTF73_RS16145 428734..429171 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GTF73_RS16150 429235..429453 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GTF73_RS16155 429628..430500 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GTF73_RS16160 430650..431249 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GTF73_RS16165 431306..431410 + 105 WP_099607150.1 acetyltransferase Antitoxin
GTF73_RS16170 431441..431710 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
GTF73_RS16175 431704..432225 + 522 WP_000921691.1 DUF2442 domain-containing protein -
GTF73_RS16180 432524..432649 + 126 WP_001905700.1 DUF645 family protein -
GTF73_RS16185 432900..433295 + 396 WP_001000867.1 hypothetical protein -
GTF73_RS16190 433434..433712 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GTF73_RS16195 433709..433993 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GTF73_RS16200 434187..434702 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
GTF73_RS16205 434759..434854 + 96 WP_099607151.1 acetyltransferase -
GTF73_RS16210 434886..435299 + 414 WP_000049420.1 VOC family protein -
GTF73_RS16215 435306..435438 - 133 Protein_486 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805
flank IS/Tn - - 428734..429171 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-74)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T145839 WP_001114075.1 NZ_CP047298:431441-431710 [Vibrio cholerae O1 biovar El Tor]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T145839 NZ_CP062702:1087173-1087508 [Escherichia coli O157:H7]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT145839 WP_099607150.1 NZ_CP047298:431306-431410 [Vibrio cholerae O1 biovar El Tor]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT145839 NZ_CP062702:1086925-1087173 [Escherichia coli O157:H7]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A086SLD6


Antitoxin

Source ID Structure

References