58380

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 166107..166685 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ83_RS15085 Protein ID WP_001180243.1
Coordinates 166107..166424 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ83_RS15090 Protein ID WP_000557292.1
Coordinates 166443..166685 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ83_RS15035 161298..161693 + 396 WP_000046952.1 hypothetical protein -
ASZ83_RS15040 161996..162177 + 182 Protein_204 DUF645 family protein -
ASZ83_RS15045 162354..162749 + 396 WP_000046953.1 hypothetical protein -
ASZ83_RS15050 162893..163429 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ83_RS15055 163726..163905 + 180 WP_001883039.1 DUF645 family protein -
ASZ83_RS15060 164101..164526 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
ASZ83_RS15065 164675..165022 + 348 WP_000933409.1 hypothetical protein -
ASZ83_RS20115 165169..165462 + 294 WP_125460920.1 hypothetical protein -
ASZ83_RS20455 165818..165913 + 96 WP_001907607.1 DUF645 family protein -
ASZ83_RS15085 166107..166424 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ83_RS15090 166443..166685 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ83_RS15095 166927..167436 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
ASZ83_RS15100 167493..168146 + 654 WP_000226874.1 hypothetical protein -
ASZ83_RS15105 168456..168674 + 219 WP_001917086.1 DUF3709 domain-containing protein -
ASZ83_RS15115 169077..169310 + 234 WP_032482776.1 DUF3709 domain-containing protein -
ASZ83_RS15120 169735..169915 + 181 Protein_218 DUF645 family protein -
ASZ83_RS15125 170182..170469 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ83_RS15130 170480..170797 + 318 WP_001232701.1 HigA family addiction module antidote protein -
ASZ83_RS20460 170794..170904 + 111 WP_134814058.1 DUF3265 domain-containing protein -
ASZ83_RS20465 171081..171206 + 126 WP_001944767.1 DUF645 family protein -
ASZ83_RS20470 171222..171260 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 87981..224211 136230
inside Integron - - 93061..221594 128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58380 WP_001180243.1 NZ_CP013316:c166424-166107 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58380 NZ_CP013316:c166424-166107 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58380 WP_000557292.1 NZ_CP013316:c166685-166443 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58380 NZ_CP013316:c166685-166443 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References