56909

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 321274..321852 Replicon chromosome
Accession NZ_CP012666
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag AN947_RS01490 Protein ID WP_001180243.1
Coordinates 321274..321591 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag AN947_RS01495 Protein ID WP_000557292.1
Coordinates 321610..321852 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN947_RS01460 316809..316991 + 183 WP_000923340.1 DUF645 family protein -
AN947_RS01465 317345..317527 + 183 WP_000923153.1 DUF645 family protein -
AN947_RS01470 317722..318399 + 678 WP_000254617.1 HNH endonuclease -
AN947_RS01475 318561..319758 + 1198 Protein_272 deoxyguanosinetriphosphate triphosphohydrolase family protein -
AN947_RS01480 319920..320624 + 705 WP_000087610.1 HNH endonuclease -
AN947_RS01485 320782..321120 + 339 WP_000713853.1 hypothetical protein -
AN947_RS01490 321274..321591 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AN947_RS01495 321610..321852 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AN947_RS01500 322096..322482 + 387 WP_001015867.1 NUDIX hydrolase -
AN947_RS01505 322539..322652 + 114 WP_001900214.1 hypothetical protein -
AN947_RS01510 322601..322882 + 282 WP_001894429.1 DUF1289 domain-containing protein -
AN947_RS01520 323140..323676 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
AN947_RS01525 323813..324328 + 516 WP_001201509.1 lipocalin family protein -
AN947_RS01535 324478..324975 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
AN947_RS01540 324972..325244 - 273 WP_000246253.1 DUF1778 domain-containing protein -
AN947_RS01550 325637..325762 + 126 WP_001900195.1 DUF645 family protein -
AN947_RS20715 325778..325816 + 39 WP_106019118.1 hypothetical protein -
AN947_RS01560 326012..326458 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304645..399892 95247
inside Integron - - 309725..399516 89791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T56909 WP_001180243.1 NZ_CP012666:c321591-321274 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T56909 NZ_CP012666:c321591-321274 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT56909 WP_000557292.1 NZ_CP012666:c321852-321610 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT56909 NZ_CP012666:c321852-321610 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References