Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 109303..110087 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag K6J77_RS14755 Protein ID WP_001114075.1
Coordinates 109303..109572 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag K6J77_RS14760 Protein ID WP_000921691.1
Coordinates 109566..110087 (+) Length 174 a.a.

Genomic Context

K6J77_RS14715K6J77_RS14720K6J77_RS14725K6J77_RS14730K6J77_RS14735K6J77_RS14740K6J77_RS14745K6J77_RS14750K6J77_RS14755K6J77_RS14760K6J77_RS14765K6J77_RS14770K6J77_RS14785K6J77_RS14790K6J77_RS14795K6J77_RS14775K6J77_RS14780
Location: 104669..105586 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 105743..106132 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 106268..106477 (210 bp)
Type: Others
Protein ID: Protein_204
Location: 106596..107033 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 107094..107315 (222 bp)
Type: Others
Protein ID: Protein_206
Location: 107490..108362 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 108512..109111 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 109168..109236 (69 bp)
Type: Others
Protein ID: Protein_209
Location: 109303..109572 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 109566..110087 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 110386..110511 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 110762..111157 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 112049..112564 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 112748..113161 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 113716..114892 (1177 bp)
Type: Others
Protein ID: WP_086014537.1
Location: 111296..111574 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 111571..111855 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J77_RS14715104669..105586+918WP_000186333.1alpha/beta hydrolase-
K6J77_RS14720105743..106132+390WP_001081302.1hypothetical protein-
K6J77_RS14725106268..106477+210Protein_204GNAT family N-acetyltransferase-
K6J77_RS14730106596..107033+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
K6J77_RS14735107094..107315+222Protein_206GNAT family N-acetyltransferase-
K6J77_RS14740107490..108362+873WP_000254716.1DUF3800 domain-containing protein-
K6J77_RS14745108512..109111+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
K6J77_RS14750109168..109236+69Protein_209acetyltransferase-
K6J77_RS14755109303..109572+270WP_001114075.1DUF4160 domain-containing proteinToxin
K6J77_RS14760109566..110087+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
K6J77_RS14765110386..110511+126WP_001905700.1DUF645 family protein-
K6J77_RS14770110762..111157+396WP_001000867.1hypothetical protein-
K6J77_RS14775111296..111574-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
K6J77_RS14780111571..111855-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
K6J77_RS14785112049..112564+516WP_000343779.1GNAT family protein-
K6J77_RS14790112748..113161+414WP_000049420.1VOC family protein-
K6J77_RS14795113716..114892+1177WP_086014537.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideIntegron--11978..113648101670
flankIS/Tn--106596..107033437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T38631 WP_001114075.1 NZ_AP024548:109303-109572 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T38631 NZ_AP024548:109303-109572 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT38631 WP_000921691.1 NZ_AP024548:109566-110087 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT38631 NZ_AP024548:109566-110087 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References