23790

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1011554..1012092 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag VCD_RS19305 Protein ID WP_000802136.1
Coordinates 1011793..1012092 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag VCD_RS19300 Protein ID WP_001107719.1
Coordinates 1011554..1011796 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS20470 1006970..1007110 - 141 WP_001883049.1 DUF3265 domain-containing protein -
VCD_RS19270 1007076..1008011 - 936 WP_000051985.1 restriction endonuclease -
VCD_RS19275 1008292..1008891 - 600 WP_000429495.1 hypothetical protein -
VCD_RS19280 1009046..1009312 - 267 WP_000937852.1 hypothetical protein -
VCD_RS19285 1009526..1010209 - 684 WP_000877436.1 hypothetical protein -
VCD_RS20480 1010633..1010725 - 93 WP_014164112.1 DUF3265 domain-containing protein -
VCD_RS19815 1010747..1011325 - 579 WP_000110120.1 hypothetical protein -
VCD_RS19300 1011554..1011796 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
VCD_RS19305 1011793..1012092 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCD_RS19310 1012220..1012615 - 396 WP_000870857.1 DUF3465 domain-containing protein -
VCD_RS19315 1012829..1013008 - 180 WP_001883058.1 DUF645 family protein -
VCD_RS20490 1013586..1013696 - 111 WP_079857360.1 DUF3265 domain-containing protein -
VCD_RS19325 1013706..1014404 - 699 WP_001890502.1 hypothetical protein -
VCD_RS19330 1014527..1015153 - 627 WP_000365424.1 LysE family translocator -
VCD_RS20495 1015195..1015287 - 93 WP_014378730.1 DUF3265 domain-containing protein -
VCD_RS19335 1015302..1015775 - 474 WP_001161076.1 GrpB family protein -
VCD_RS19340 1015975..1016157 - 183 WP_000923182.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932253..1057432 125179
inside Integron - - 958376..1050596 92220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T23790 WP_000802136.1 NC_012667:1011793-1012092 [Vibrio cholerae MJ-1236]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T23790 NC_012667:1011793-1012092 [Vibrio cholerae MJ-1236]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT23790 WP_001107719.1 NC_012667:1011554-1011796 [Vibrio cholerae MJ-1236]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT23790 NC_012667:1011554-1011796 [Vibrio cholerae MJ-1236]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References