58402

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 460364..460892 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag ASZ85_RS16855 Protein ID WP_000221352.1
Coordinates 460364..460654 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag ASZ85_RS16860 Protein ID WP_000213183.1
Coordinates 460644..460892 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ85_RS21465 455921..456046 + 126 WP_001944767.1 DUF645 family protein -
ASZ85_RS21470 456062..456100 + 39 WP_106019119.1 hypothetical protein -
ASZ85_RS16825 456313..457317 + 1005 WP_000964925.1 LD-carboxypeptidase -
ASZ85_RS16830 457470..457916 + 447 WP_000128977.1 hypothetical protein -
ASZ85_RS16835 458036..458965 + 930 WP_000335802.1 hypothetical protein -
ASZ85_RS21175 458962..459072 + 111 WP_071917832.1 DUF3265 domain-containing protein -
ASZ85_RS16845 459100..459576 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
ASZ85_RS16850 459713..460228 + 516 WP_001201532.1 lipocalin family protein -
ASZ85_RS16855 460364..460654 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ85_RS16860 460644..460892 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ85_RS16870 461463..462116 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
ASZ85_RS16875 462388..462813 + 426 WP_000415748.1 hypothetical protein -
ASZ85_RS16880 463021..463416 + 396 WP_000649527.1 DUF3465 domain-containing protein -
ASZ85_RS16885 463567..464097 + 531 WP_000415563.1 hypothetical protein -
ASZ85_RS16890 464235..464735 + 501 WP_000789723.1 hypothetical protein -
ASZ85_RS16895 464891..465289 + 399 WP_001882293.1 hypothetical protein -
ASZ85_RS16900 465389..465853 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 338285..496833 158548
inside Integron - - 343365..496457 153092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T58402 WP_000221352.1 NZ_CP013318:c460654-460364 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T58402 NZ_CP013318:c460654-460364 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT58402 WP_000213183.1 NZ_CP013318:c460892-460644 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT58402 NZ_CP013318:c460892-460644 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References