Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 460364..460892 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag ASZ85_RS16855 Protein ID WP_000221352.1
Coordinates 460364..460654 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag ASZ85_RS16860 Protein ID WP_000213183.1
Coordinates 460644..460892 (-) Length 83 a.a.

Genomic Context

ASZ85_RS21465ASZ85_RS21470ASZ85_RS16825ASZ85_RS16830ASZ85_RS16835ASZ85_RS21175ASZ85_RS16845ASZ85_RS16850ASZ85_RS16870ASZ85_RS16875ASZ85_RS16880ASZ85_RS16885ASZ85_RS16890ASZ85_RS16895ASZ85_RS16855ASZ85_RS16860ASZ85_RS16900
Location: 455921..456046 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 456062..456100 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 456313..457317 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 457470..457916 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 458036..458965 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 458962..459072 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 459100..459576 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 459713..460228 (516 bp)
Type: Others
Protein ID: WP_001201532.1
Location: 461463..462116 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 462388..462813 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 463021..463416 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 463567..464097 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 464235..464735 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 464891..465289 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 460364..460654 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 460644..460892 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 465389..465853 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ85_RS21465455921..456046+126WP_001944767.1DUF645 family protein-
ASZ85_RS21470456062..456100+39WP_106019119.1hypothetical protein-
ASZ85_RS16825456313..457317+1005WP_000964925.1LD-carboxypeptidase-
ASZ85_RS16830457470..457916+447WP_000128977.1hypothetical protein-
ASZ85_RS16835458036..458965+930WP_000335802.1hypothetical protein-
ASZ85_RS21175458962..459072+111WP_071917832.1DUF3265 domain-containing protein-
ASZ85_RS16845459100..459576+477WP_001047180.1GNAT family N-acetyltransferase-
ASZ85_RS16850459713..460228+516WP_001201532.1lipocalin family protein-
ASZ85_RS16855460364..460654-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ85_RS16860460644..460892-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ85_RS16870461463..462116+654WP_000036957.1site-specific DNA-methyltransferase-
ASZ85_RS16875462388..462813+426WP_000415748.1hypothetical protein-
ASZ85_RS16880463021..463416+396WP_000649527.1DUF3465 domain-containing protein-
ASZ85_RS16885463567..464097+531WP_000415563.1hypothetical protein-
ASZ85_RS16890464235..464735+501WP_000789723.1hypothetical protein-
ASZ85_RS16895464891..465289+399WP_001882293.1hypothetical protein-
ASZ85_RS16900465389..465853-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--338285..496833158548
insideIntegron--343365..496457153092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T58402 WP_000221352.1 NZ_CP013318:c460654-460364 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T58402 NZ_CP013318:c460654-460364 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT58402 WP_000213183.1 NZ_CP013318:c460892-460644 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT58402 NZ_CP013318:c460892-460644 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References