Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 332625..333123 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag VCA1552_RS15865 Protein ID WP_000589156.1
Coordinates 332625..332891 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag VCA1552_RS15870 Protein ID WP_000643598.1
Coordinates 332878..333123 (+) Length 82 a.a.

Genomic Context

VCA1552_RS15805VCA1552_RS15810VCA1552_RS15815VCA1552_RS15820VCA1552_RS15825VCA1552_RS15830VCA1552_RS15835VCA1552_RS19985VCA1552_RS19990VCA1552_RS15850VCA1552_RS15855VCA1552_RS15865VCA1552_RS15870VCA1552_RS15875VCA1552_RS19995VCA1552_RS15890VCA1552_RS15895VCA1552_RS15900VCA1552_RS15905VCA1552_RS15910VCA1552_RS15915
Location: 328045..328251 (207 bp)
Type: Others
Protein ID: Protein_290
Location: 328451..328552 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 328542..328928 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 329123..329374 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 329347..329496 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 329588..329830 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 330082..330360 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 330735..330878 (144 bp)
Type: Others
Protein ID: Protein_297
Location: 330932..330970 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 331182..331649 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 331777..332440 (664 bp)
Type: Others
Protein ID: Protein_300
Location: 332625..332891 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 332878..333123 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 333219..334013 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 334116..334244 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 334305..334487 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 334703..335707 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 335860..336219 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 336492..336725 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 336993..337499 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 337656..338042 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS15805328045..328251+207Protein_290DUF3709 domain-containing protein-
VCA1552_RS15810328451..328552+102WP_001921603.1hypothetical protein-
VCA1552_RS15815328542..328928+387WP_000703163.1VOC family protein-
VCA1552_RS15820329123..329374+252WP_001890111.1TIGR03643 family protein-
VCA1552_RS15825329347..329496+150WP_071908333.1DUF3265 domain-containing protein-
VCA1552_RS15830329588..329830+243WP_000107461.1hypothetical protein-
VCA1552_RS15835330082..330360+279WP_000280324.1DUF3709 domain-containing protein-
VCA1552_RS19985330735..330878+144Protein_297DUF645 family protein-
VCA1552_RS19990330932..330970+39WP_082798268.1hypothetical protein-
VCA1552_RS15850331182..331649+468WP_001289288.1OsmC family protein-
VCA1552_RS15855331777..332440+664Protein_300hypothetical protein-
VCA1552_RS15865332625..332891+267WP_000589156.1BrnT family toxinToxin
VCA1552_RS15870332878..333123+246WP_000643598.1hypothetical proteinAntitoxin
VCA1552_RS15875333219..334013+795WP_001911581.1hypothetical protein-
VCA1552_RS19995334116..334244+129WP_071908338.1general secretion pathway protein GspI-
VCA1552_RS15890334305..334487+183WP_000923182.1DUF645 family protein-
VCA1552_RS15895334703..335707+1005WP_000964920.1LD-carboxypeptidase-
VCA1552_RS15900335860..336219+360WP_001071541.1VOC family protein-
VCA1552_RS15905336492..336725+234WP_001890112.1DUF3709 domain-containing protein-
VCA1552_RS15910336993..337499+507WP_000393074.1hypothetical protein-
VCA1552_RS15915337656..338042+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304717..433978129261
insideIntegron--309797..433602123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T88990 WP_000589156.1 NZ_CP024868:332625-332891 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T88990 NZ_CP024868:332625-332891 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT88990 WP_000643598.1 NZ_CP024868:332878-333123 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT88990 NZ_CP024868:332878-333123 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References