Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 841051..841610 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag A6J62_RS04310 Protein ID WP_000578476.1
Coordinates 841332..841610 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag A6J62_RS04305 Protein ID WP_000381183.1
Coordinates 841051..841335 (+) Length 95 a.a.

Genomic Context

A6J62_RS04305A6J62_RS04310A6J62_RS04260A6J62_RS04265A6J62_RS04270A6J62_RS04275A6J62_RS04280A6J62_RS04285A6J62_RS04295A6J62_RS04300A6J62_RS04315A6J62_RS04325A6J62_RS04330A6J62_RS04335A6J62_RS04340A6J62_RS04345A6J62_RS04350A6J62_RS04355A6J62_RS04360
Location: 841051..841335 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 841332..841610 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 836717..836827 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 836837..837535 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 837658..838284 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 838326..838418 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 838433..838906 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 839106..839288 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 839680..840276 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 840341..840856 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 841761..842174 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 842362..842841 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 843054..843677 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 843883..844308 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 844455..844604 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 844577..844828 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 845023..845226 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 845483..845869 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 846026..846532 (507 bp)
Type: Others
Protein ID: WP_000393074.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A6J62_RS04260836717..836827-111WP_079857360.1DUF3265 domain-containing protein-
A6J62_RS04265836837..837535-699WP_001890502.1hypothetical protein-
A6J62_RS04270837658..838284-627WP_000365424.1LysE family translocator-
A6J62_RS04275838326..838418-93WP_014378730.1DUF3265 domain-containing protein-
A6J62_RS04280838433..838906-474WP_001161076.1GrpB family protein-
A6J62_RS04285839106..839288-183WP_000923182.1DUF645 family protein-
A6J62_RS04295839680..840276-597WP_000255434.1hypothetical protein-
A6J62_RS04300840341..840856-516WP_001201520.1lipocalin family protein-
A6J62_RS04305841051..841335+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
A6J62_RS04310841332..841610+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
A6J62_RS04315841761..842174-414WP_000049420.1VOC family protein-
A6J62_RS04325842362..842841-480WP_000009888.1lecithin retinol acyltransferase family protein-
A6J62_RS04330843054..843677-624WP_000247070.1DUF1349 domain-containing protein-
A6J62_RS04335843883..844308-426WP_000415750.1hypothetical protein-
A6J62_RS04340844455..844604-150WP_071908333.1DUF3265 domain-containing protein-
A6J62_RS04345844577..844828-252WP_001890111.1TIGR03643 family protein-
A6J62_RS04350845023..845226-204WP_001911580.1hypothetical protein-
A6J62_RS04355845483..845869-387WP_000703163.1VOC family protein-
A6J62_RS04360846026..846532-507WP_000393074.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-749087..881909132822
insideIntegron--749463..875103125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T74627 WP_000578476.1 NZ_CP020407:841332-841610 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T74627 NZ_CP020407:841332-841610 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT74627 WP_000381183.1 NZ_CP020407:841051-841335 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT74627 NZ_CP020407:841051-841335 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A067BL33

References