74627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 841051..841610 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag A6J62_RS04310 Protein ID WP_000578476.1
Coordinates 841332..841610 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag A6J62_RS04305 Protein ID WP_000381183.1
Coordinates 841051..841335 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J62_RS04260 836717..836827 - 111 WP_079857360.1 DUF3265 domain-containing protein -
A6J62_RS04265 836837..837535 - 699 WP_001890502.1 hypothetical protein -
A6J62_RS04270 837658..838284 - 627 WP_000365424.1 LysE family translocator -
A6J62_RS04275 838326..838418 - 93 WP_014378730.1 DUF3265 domain-containing protein -
A6J62_RS04280 838433..838906 - 474 WP_001161076.1 GrpB family protein -
A6J62_RS04285 839106..839288 - 183 WP_000923182.1 DUF645 family protein -
A6J62_RS04295 839680..840276 - 597 WP_000255434.1 hypothetical protein -
A6J62_RS04300 840341..840856 - 516 WP_001201520.1 lipocalin family protein -
A6J62_RS04305 841051..841335 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A6J62_RS04310 841332..841610 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
A6J62_RS04315 841761..842174 - 414 WP_000049420.1 VOC family protein -
A6J62_RS04325 842362..842841 - 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
A6J62_RS04330 843054..843677 - 624 WP_000247070.1 DUF1349 domain-containing protein -
A6J62_RS04335 843883..844308 - 426 WP_000415750.1 hypothetical protein -
A6J62_RS04340 844455..844604 - 150 WP_071908333.1 DUF3265 domain-containing protein -
A6J62_RS04345 844577..844828 - 252 WP_001890111.1 TIGR03643 family protein -
A6J62_RS04350 845023..845226 - 204 WP_001911580.1 hypothetical protein -
A6J62_RS04355 845483..845869 - 387 WP_000703163.1 VOC family protein -
A6J62_RS04360 846026..846532 - 507 WP_000393074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 749087..881909 132822
inside Integron - - 749463..875103 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T74627 WP_000578476.1 NZ_CP020407:841332-841610 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T74627 NZ_CP020407:841332-841610 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT74627 WP_000381183.1 NZ_CP020407:841051-841335 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT74627 NZ_CP020407:841051-841335 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References