198989

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 420412..420940 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag J9265_RS16025 Protein ID WP_000221354.1
Coordinates 420653..420940 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag J9265_RS16020 Protein ID WP_001250179.1
Coordinates 420412..420663 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9265_RS15975 (J9265_15975) 415680..415994 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
J9265_RS15980 (J9265_15980) 416131..416565 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
J9265_RS15985 (J9265_15985) 416733..416888 + 156 WP_000751734.1 hypothetical protein -
J9265_RS15990 (J9265_15990) 417013..417993 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
J9265_RS15995 (J9265_15995) 418061..418367 + 307 Protein_471 CatB-related O-acetyltransferase -
J9265_RS19165 418504..418902 + 399 Protein_472 GNAT family N-acetyltransferase -
J9265_RS19170 419026..419196 + 171 WP_001080654.1 hypothetical protein -
J9265_RS16005 (J9265_16005) 419196..419597 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
J9265_RS16010 (J9265_16010) 419600..419710 + 111 WP_082798255.1 DUF3265 domain-containing protein -
J9265_RS16015 (J9265_16015) 419785..420198 + 414 WP_000049417.1 VOC family protein -
J9265_RS16020 (J9265_16020) 420412..420663 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J9265_RS16025 (J9265_16025) 420653..420940 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9265_RS16030 (J9265_16030) 421068..421523 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
J9265_RS19175 421580..421702 + 123 Protein_480 acetyltransferase -
J9265_RS16035 (J9265_16035) 421873..421997 + 125 Protein_481 DUF645 family protein -
J9265_RS19180 422114..422182 + 69 Protein_482 acetyltransferase -
J9265_RS16040 (J9265_16040) 422199..422696 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
J9265_RS16045 (J9265_16045) 422693..422965 - 273 WP_000246253.1 DUF1778 domain-containing protein -
J9265_RS19185 423117..423179 + 63 Protein_485 acetyltransferase -
J9265_RS16050 (J9265_16050) 423196..423864 + 669 WP_000043871.1 hypothetical protein -
J9265_RS16055 (J9265_16055) 424016..424303 + 288 WP_000426470.1 hypothetical protein -
J9265_RS16060 (J9265_16060) 424444..424815 + 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
J9265_RS19190 425038..425307 + 270 WP_000179600.1 DUF1778 domain-containing protein -
J9265_RS16070 (J9265_16070) 425304..425837 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 311994..435799 123805
flank IS/Tn - - 417013..417993 980
- inside Genomic island catB9 - 306914..436175 129261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T198989 WP_000221354.1 NZ_CP072848:420653-420940 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T198989 NZ_CP097082:326729-327097 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCTGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT198989 WP_001250179.1 NZ_CP072848:420412-420663 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT198989 NZ_CP097082:326511-326732 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References