Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 350616..351154 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GTF74_RS15445 Protein ID WP_000802136.1
Coordinates 350616..350915 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GTF74_RS15450 Protein ID WP_001107719.1
Coordinates 350912..351154 (-) Length 81 a.a.

Genomic Context

GTF74_RS15405GTF74_RS15410GTF74_RS15415GTF74_RS15420GTF74_RS15425GTF74_RS15430GTF74_RS15435GTF74_RS15440GTF74_RS15455GTF74_RS15460GTF74_RS15465GTF74_RS15470GTF74_RS15475GTF74_RS15480GTF74_RS15485GTF74_RS15445GTF74_RS15450
Location: 346551..346733 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 346933..347406 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 347403..347513 (111 bp)
Type: Others
Protein ID: WP_071908312.1
Location: 347555..348181 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 348304..349002 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 349006..349122 (117 bp)
Type: Others
Protein ID: WP_071908339.1
Location: 349700..349879 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 350093..350488 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 351383..351961 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 351965..352075 (111 bp)
Type: Others
Protein ID: WP_071908313.1
Location: 352499..353182 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 353396..353662 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 353817..354416 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 354697..355632 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 355598..355738 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 350616..350915 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 350912..351154 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF74_RS15405346551..346733+183WP_000923182.1DUF645 family protein-
GTF74_RS15410346933..347406+474WP_001161076.1GrpB family protein-
GTF74_RS15415347403..347513+111WP_071908312.1DUF3265 domain-containing protein-
GTF74_RS15420347555..348181+627WP_000365424.1LysE family translocator-
GTF74_RS15425348304..349002+699WP_001890502.1hypothetical protein-
GTF74_RS15430349006..349122+117WP_071908339.1DUF3265 domain-containing protein-
GTF74_RS15435349700..349879+180WP_001883058.1DUF645 family protein-
GTF74_RS15440350093..350488+396WP_000870857.1DUF3465 domain-containing protein-
GTF74_RS15445350616..350915-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GTF74_RS15450350912..351154-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
GTF74_RS15455351383..351961+579WP_000110120.1hypothetical protein-
GTF74_RS15460351965..352075+111WP_071908313.1DUF3265 domain-containing protein-
GTF74_RS15465352499..353182+684WP_000877436.1hypothetical protein-
GTF74_RS15470353396..353662+267WP_000937852.1hypothetical protein-
GTF74_RS15475353817..354416+600WP_000429495.1hypothetical protein-
GTF74_RS15480354697..355632+936WP_000051985.1restriction endonuclease-
GTF74_RS15485355598..355738+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-307032..436751129719
insideIntegron--312112..436375124263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T145888 WP_000802136.1 NZ_CP047304:c350915-350616 [Vibrio cholerae O1 biovar El Tor]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145888 NZ_CP062706:2066-2341 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT145888 WP_001107719.1 NZ_CP047304:c351154-350912 [Vibrio cholerae O1 biovar El Tor]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145888 NZ_CP062706:1782-2066 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References