145888

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 350616..351154 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GTF74_RS15445 Protein ID WP_000802136.1
Coordinates 350616..350915 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GTF74_RS15450 Protein ID WP_001107719.1
Coordinates 350912..351154 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF74_RS15405 346551..346733 + 183 WP_000923182.1 DUF645 family protein -
GTF74_RS15410 346933..347406 + 474 WP_001161076.1 GrpB family protein -
GTF74_RS15415 347403..347513 + 111 WP_071908312.1 DUF3265 domain-containing protein -
GTF74_RS15420 347555..348181 + 627 WP_000365424.1 LysE family translocator -
GTF74_RS15425 348304..349002 + 699 WP_001890502.1 hypothetical protein -
GTF74_RS15430 349006..349122 + 117 WP_071908339.1 DUF3265 domain-containing protein -
GTF74_RS15435 349700..349879 + 180 WP_001883058.1 DUF645 family protein -
GTF74_RS15440 350093..350488 + 396 WP_000870857.1 DUF3465 domain-containing protein -
GTF74_RS15445 350616..350915 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF74_RS15450 350912..351154 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GTF74_RS15455 351383..351961 + 579 WP_000110120.1 hypothetical protein -
GTF74_RS15460 351965..352075 + 111 WP_071908313.1 DUF3265 domain-containing protein -
GTF74_RS15465 352499..353182 + 684 WP_000877436.1 hypothetical protein -
GTF74_RS15470 353396..353662 + 267 WP_000937852.1 hypothetical protein -
GTF74_RS15475 353817..354416 + 600 WP_000429495.1 hypothetical protein -
GTF74_RS15480 354697..355632 + 936 WP_000051985.1 restriction endonuclease -
GTF74_RS15485 355598..355738 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 307032..436751 129719
inside Integron - - 312112..436375 124263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T145888 WP_000802136.1 NZ_CP047304:c350915-350616 [Vibrio cholerae O1 biovar El Tor]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145888 NZ_CP062706:2066-2341 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT145888 WP_001107719.1 NZ_CP047304:c351154-350912 [Vibrio cholerae O1 biovar El Tor]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145888 NZ_CP062706:1782-2066 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References