58409

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 491977..492381 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ85_RS17185 Protein ID WP_001114075.1
Coordinates 492112..492381 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ85_RS21230 Protein ID WP_099607150.1
Coordinates 491977..492081 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ85_RS17140 487478..488395 + 918 WP_000186333.1 alpha/beta hydrolase -
ASZ85_RS17150 488552..488941 + 390 WP_001081302.1 hypothetical protein -
ASZ85_RS17155 489077..489286 + 210 Protein_549 GNAT family N-acetyltransferase -
ASZ85_RS17160 489405..489842 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
ASZ85_RS17165 489906..490124 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
ASZ85_RS17175 490299..491171 + 873 WP_000254716.1 DUF3800 domain-containing protein -
ASZ85_RS17180 491321..491920 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
ASZ85_RS21230 491977..492081 + 105 WP_099607150.1 acetyltransferase Antitoxin
ASZ85_RS17185 492112..492381 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
ASZ85_RS17190 492375..492896 + 522 WP_000921691.1 DUF2442 domain-containing protein -
ASZ85_RS21235 493195..493320 + 126 WP_001905700.1 DUF645 family protein -
ASZ85_RS17205 493571..493966 + 396 WP_001000867.1 hypothetical protein -
ASZ85_RS17210 494105..494383 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
ASZ85_RS17215 494380..494664 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ85_RS17220 494858..495373 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
ASZ85_RS17225 495557..495970 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 338285..496833 158548
inside Integron - - 343365..496457 153092
flank IS/Tn - - 489405..489842 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58409 WP_001114075.1 NZ_CP013318:492112-492381 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58409 NZ_CP013318:492112-492381 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT58409 WP_099607150.1 NZ_CP013318:491977-492081 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT58409 NZ_CP013318:491977-492081 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References