125046

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 962078..962606 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag FDZ90_RS19235 Protein ID WP_000221354.1
Coordinates 962319..962606 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag FDZ90_RS19230 Protein ID WP_001250179.1
Coordinates 962078..962329 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDZ90_RS19185 957347..957661 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
FDZ90_RS19190 957798..958232 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
FDZ90_RS19195 958400..958555 + 156 WP_000751734.1 hypothetical protein -
FDZ90_RS19200 958680..959659 - 980 Protein_893 IS5-like element ISVch5 family transposase -
FDZ90_RS19205 959727..959999 + 273 Protein_894 CatB-related O-acetyltransferase -
FDZ90_RS19210 960170..960862 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
FDZ90_RS19215 960862..961263 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
FDZ90_RS19220 961233..961376 + 144 WP_071908341.1 DUF3265 domain-containing protein -
FDZ90_RS19225 961451..961864 + 414 WP_000049417.1 VOC family protein -
FDZ90_RS19230 962078..962329 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FDZ90_RS19235 962319..962606 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDZ90_RS19240 962734..963189 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
FDZ90_RS19245 963511..963663 + 153 WP_001884520.1 DUF645 family protein -
FDZ90_RS19250 963865..964362 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
FDZ90_RS19255 964359..964631 - 273 WP_000246253.1 DUF1778 domain-containing protein -
FDZ90_RS19260 964862..965530 + 669 WP_000043871.1 hypothetical protein -
FDZ90_RS19265 965682..965969 + 288 WP_000426470.1 hypothetical protein -
FDZ90_RS19270 966110..966481 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
FDZ90_RS19275 966548..966973 + 426 WP_001882332.1 DUF1778 domain-containing protein -
FDZ90_RS19280 966970..967503 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 882589..977840 95251
inside Integron catB9 - 887669..977464 89795
flank IS/Tn - - 958940..959659 719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T125046 WP_000221354.1 NZ_CP040173:962319-962606 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T125046 NZ_CP040173:962319-962606 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT125046 WP_001250179.1 NZ_CP040173:962078-962329 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT125046 NZ_CP040173:962078-962329 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References