Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 332880..333418 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ80_RS15790 Protein ID WP_000802136.1
Coordinates 332880..333179 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ80_RS15795 Protein ID WP_001107719.1
Coordinates 333176..333418 (-) Length 81 a.a.

Genomic Context

ASZ80_RS15730ASZ80_RS15735ASZ80_RS15740ASZ80_RS15745ASZ80_RS20940ASZ80_RS15750ASZ80_RS15760ASZ80_RS15765ASZ80_RS15770ASZ80_RS15805ASZ80_RS20860ASZ80_RS20945ASZ80_RS20420ASZ80_RS15830ASZ80_RS15840ASZ80_RS15850ASZ80_RS15855ASZ80_RS15775ASZ80_RS15780ASZ80_RS15790ASZ80_RS15795
Location: 328085..328267 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 328482..329021 (540 bp)
Type: Others
Protein ID: WP_000099372.1
Location: 329144..329659 (516 bp)
Type: Others
Protein ID: WP_000090011.1
Location: 329794..330330 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 330449..330610 (162 bp)
Type: Others
Protein ID: WP_000481782.1
Location: 330799..330909 (111 bp)
Type: Others
Protein ID: WP_071908335.1
Location: 331122..331274 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 331558..332001 (444 bp)
Type: Others
Protein ID: WP_000803902.1
Location: 332005..332115 (111 bp)
Type: Others
Protein ID: WP_071908336.1
Location: 333837..333914 (78 bp)
Type: Others
Protein ID: WP_071908337.1
Location: 333918..333944 (27 bp)
Type: Others
Protein ID: Protein_299
Location: 334530..334673 (144 bp)
Type: Others
Protein ID: WP_001900215.1
Location: 334767..334946 (180 bp)
Type: Others
Protein ID: Protein_301
Location: 335164..335592 (429 bp)
Type: Others
Protein ID: WP_000620002.1
Location: 336180..336662 (483 bp)
Type: Others
Protein ID: WP_000422940.1
Location: 337470..337739 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 337733..338254 (522 bp)
Type: Others
Protein ID: WP_000921692.1
Location: 332145..332423 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 332420..332704 (285 bp)
Type: Others
Protein ID: WP_000381183.1
Location: 332880..333179 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 333176..333418 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ80_RS15730328085..328267+183WP_000923340.1DUF645 family protein-
ASZ80_RS15735328482..329021+540WP_000099372.1hypothetical protein-
ASZ80_RS15740329144..329659+516WP_000090011.1hypothetical protein-
ASZ80_RS15745329794..330330+537WP_000644491.1nucleotidyltransferase family protein-
ASZ80_RS20940330449..330610+162WP_000481782.1hypothetical protein-
ASZ80_RS15750330799..330909+111WP_071908335.1DUF3265 domain-containing protein-
ASZ80_RS15760331122..331274+153WP_001884520.1DUF645 family protein-
ASZ80_RS15765331558..332001+444WP_000803902.1hypothetical protein-
ASZ80_RS15770332005..332115+111WP_071908336.1DUF3265 domain-containing protein-
ASZ80_RS15775332145..332423-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
ASZ80_RS15780332420..332704-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ80_RS15790332880..333179-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ80_RS15795333176..333418-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
ASZ80_RS15805333837..333914+78WP_071908337.1DUF645 family protein-
ASZ80_RS20860333918..333944+27Protein_299hypothetical protein-
ASZ80_RS20945334530..334673+144WP_001900215.1hypothetical protein-
ASZ80_RS20420334767..334946+180Protein_301DUF645 family protein-
ASZ80_RS15830335164..335592+429WP_000620002.1N-acetyltransferase-
ASZ80_RS15840336180..336662+483WP_000422940.1GNAT family N-acetyltransferase-
ASZ80_RS15850337470..337739+270WP_001114075.1DUF4160 domain-containing protein-
ASZ80_RS15855337733..338254+522WP_000921692.1DUF2442 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304694..469286164592
insideIntegron--309774..468910159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58215 WP_000802136.1 NZ_CP013302:c333179-332880 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58215 NZ_CP013302:c333179-332880 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCCGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58215 WP_001107719.1 NZ_CP013302:c333418-333176 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58215 NZ_CP013302:c333418-333176 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References