Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 425316..426082 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GTF71_RS15770 Protein ID WP_000982260.1
Coordinates 425316..425813 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GTF71_RS15775 Protein ID WP_000246253.1
Coordinates 425810..426082 (-) Length 91 a.a.

Genomic Context

GTF71_RS15725GTF71_RS15730GTF71_RS15735GTF71_RS15740GTF71_RS15745GTF71_RS15750GTF71_RS15755GTF71_RS15760GTF71_RS15765GTF71_RS15780GTF71_RS15785GTF71_RS15790GTF71_RS15795GTF71_RS15800GTF71_RS15805GTF71_RS15810GTF71_RS15815GTF71_RS15770GTF71_RS15775
Location: 421178..421450 (273 bp)
Type: Others
Protein ID: Protein_455
Location: 421621..422313 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 422313..422714 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 422684..422827 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 422902..423315 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 423529..423780 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 423770..424057 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 424185..424640 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 424962..425114 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 426313..426981 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 427133..427420 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 427561..427932 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 427999..428424 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 428421..428954 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 429156..429413 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 429401..429703 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 429937..430854 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 425316..425813 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 425810..426082 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF71_RS15725421178..421450+273Protein_455CatB-related O-acetyltransferase-
GTF71_RS15730421621..422313+693WP_001047169.1GNAT family N-acetyltransferase-
GTF71_RS15735422313..422714+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
GTF71_RS15740422684..422827+144WP_071908341.1DUF3265 domain-containing protein-
GTF71_RS15745422902..423315+414WP_000049417.1VOC family protein-
GTF71_RS15750423529..423780+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF71_RS15755423770..424057+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF71_RS15760424185..424640+456WP_001245327.1GNAT family N-acetyltransferase-
GTF71_RS15765424962..425114+153WP_001884520.1DUF645 family protein-
GTF71_RS15770425316..425813-498WP_000982260.1GNAT family N-acetyltransferaseToxin
GTF71_RS15775425810..426082-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
GTF71_RS15780426313..426981+669WP_000043871.1hypothetical protein-
GTF71_RS15785427133..427420+288WP_000426470.1hypothetical protein-
GTF71_RS15790427561..427932+372WP_001164080.1nucleotide pyrophosphohydrolase-
GTF71_RS15795427999..428424+426WP_001882332.1DUF1778 domain-containing protein-
GTF71_RS15800428421..428954+534WP_000118351.1GNAT family N-acetyltransferase-
GTF71_RS15805429156..429413+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF71_RS15810429401..429703+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF71_RS15815429937..430854+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306926..439292132366
insideIntegron--312006..438916126910
flankIS/Tn--420130..421110980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145856 WP_000982260.1 NZ_CP047300:c425813-425316 [Vibrio cholerae O1 biovar El Tor]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145856 NZ_CP062702:c4896361-4896011 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145856 WP_000246253.1 NZ_CP047300:c426082-425810 [Vibrio cholerae O1 biovar El Tor]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145856 NZ_CP062702:c4896606-4896355 [Escherichia coli O157:H7]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References