Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 433217..433621 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag N16961_RS16680 Protein ID WP_001114075.1
Coordinates 433352..433621 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag N16961_RS16675 Protein ID WP_099607150.1
Coordinates 433217..433321 (+) Length 35 a.a.

Genomic Context

N16961_RS16640N16961_RS16645N16961_RS16650N16961_RS16655N16961_RS16660N16961_RS16665N16961_RS16670N16961_RS16675N16961_RS16680N16961_RS16685N16961_RS16690N16961_RS16700N16961_RS16715N16961_RS16725N16961_RS16705N16961_RS16710
Location: 428718..429635 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 429792..430181 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 430317..430526 (210 bp)
Type: Others
Protein ID: Protein_468
Location: 430645..431082 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 431146..431364 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 431539..432411 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 432561..433160 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 433217..433321 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 433352..433621 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 433615..434136 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 434435..434560 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 434811..435206 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 436098..436613 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 436797..437210 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 435345..435623 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 435620..435904 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N16961_RS16640428718..429635+918WP_000186333.1alpha/beta hydrolase-
N16961_RS16645429792..430181+390WP_001081302.1hypothetical protein-
N16961_RS16650430317..430526+210Protein_468GNAT family N-acetyltransferase-
N16961_RS16655430645..431082+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
N16961_RS16660431146..431364+219WP_071908318.1GNAT family N-acetyltransferase-
N16961_RS16665431539..432411+873WP_000254716.1DUF3800 domain-containing protein-
N16961_RS16670432561..433160+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
N16961_RS16675433217..433321+105WP_099607150.1acetyltransferaseAntitoxin
N16961_RS16680433352..433621+270WP_001114075.1DUF4160 domain-containing proteinToxin
N16961_RS16685433615..434136+522WP_000921691.1DUF2442 domain-containing protein-
N16961_RS16690434435..434560+126WP_001905700.1DUF645 family protein-
N16961_RS16700434811..435206+396WP_001000867.1hypothetical protein-
N16961_RS16705435345..435623-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
N16961_RS16710435620..435904-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
N16961_RS16715436098..436613+516WP_000343779.1GNAT family N-acetyltransferase-
N16961_RS16725436797..437210+414WP_000049420.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306977..438073131096
insideIntegron--312057..437697125640
flankIS/Tn--430645..431082437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T104262 WP_001114075.1 NZ_CP028828:433352-433621 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T104262 NZ_CP028828:433352-433621 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT104262 WP_099607150.1 NZ_CP028828:433217-433321 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT104262 NZ_CP028828:433217-433321 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References