104262

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 433217..433621 Replicon chromosome
Accession NZ_CP028828
Organism Vibrio cholerae strain N16961

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag N16961_RS16680 Protein ID WP_001114075.1
Coordinates 433352..433621 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag N16961_RS16675 Protein ID WP_099607150.1
Coordinates 433217..433321 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N16961_RS16640 428718..429635 + 918 WP_000186333.1 alpha/beta hydrolase -
N16961_RS16645 429792..430181 + 390 WP_001081302.1 hypothetical protein -
N16961_RS16650 430317..430526 + 210 Protein_468 GNAT family N-acetyltransferase -
N16961_RS16655 430645..431082 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
N16961_RS16660 431146..431364 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
N16961_RS16665 431539..432411 + 873 WP_000254716.1 DUF3800 domain-containing protein -
N16961_RS16670 432561..433160 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
N16961_RS16675 433217..433321 + 105 WP_099607150.1 acetyltransferase Antitoxin
N16961_RS16680 433352..433621 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
N16961_RS16685 433615..434136 + 522 WP_000921691.1 DUF2442 domain-containing protein -
N16961_RS16690 434435..434560 + 126 WP_001905700.1 DUF645 family protein -
N16961_RS16700 434811..435206 + 396 WP_001000867.1 hypothetical protein -
N16961_RS16705 435345..435623 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
N16961_RS16710 435620..435904 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
N16961_RS16715 436098..436613 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
N16961_RS16725 436797..437210 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306977..438073 131096
inside Integron - - 312057..437697 125640
flank IS/Tn - - 430645..431082 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T104262 WP_001114075.1 NZ_CP028828:433352-433621 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T104262 NZ_CP028828:433352-433621 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT104262 WP_099607150.1 NZ_CP028828:433217-433321 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT104262 NZ_CP028828:433217-433321 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References