Detailed information of TA system TA095387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 122258..123024
• Replicon: chromosome
• Accession: NZ_CP026648
• Organism: Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9K2P7
• Locus tag: C4E16_RS15195
• Protein ID: WP_000982260.1
• Coordinates: 122258..122755 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9K2J6
• Locus tag: C4E16_RS15200
• Protein ID: WP_000246253.1
• Coordinates: 122752..123024 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4E16_RS15145	118120..118426	+	307	Protein_182	CatB-related O-acetyltransferase	-
C4E16_RS15150	118563..119255	+	693	WP_001047169.1	GNAT family N-acetyltransferase	-
C4E16_RS15155	119255..119656	+	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	-
C4E16_RS15160	119626..119769	+	144	WP_071908341.1	DUF3265 domain-containing protein	-
C4E16_RS15165	119844..120257	+	414	WP_000049417.1	VOC family protein	-
C4E16_RS15170	120471..120722	+	252	WP_001250179.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
C4E16_RS15175	120712..120999	+	288	WP_000221354.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C4E16_RS15180	121127..121582	+	456	WP_001245327.1	GNAT family N-acetyltransferase	-
C4E16_RS15185	121904..122056	+	153	WP_001884520.1	DUF645 family protein	-
C4E16_RS15195	122258..122755	-	498	WP_000982260.1	GNAT family N-acetyltransferase	Toxin
C4E16_RS15200	122752..123024	-	273	WP_000246253.1	DUF1778 domain-containing protein	Antitoxin
C4E16_RS15205	123255..123923	+	669	WP_000043871.1	hypothetical protein	-
C4E16_RS15210	124075..124362	+	288	WP_000426470.1	hypothetical protein	-
C4E16_RS15215	124503..124874	+	372	WP_001164080.1	nucleotide pyrophosphohydrolase	-
C4E16_RS19585	124941..125366	+	426	WP_001882332.1	DUF1778 domain-containing protein	-
C4E16_RS15225	125363..125896	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
C4E16_RS15235	126098..126355	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
C4E16_RS15240	126343..126645	+	303	WP_000229317.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C4E16_RS15250	126879..127796	+	918	WP_000186333.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	31043..136234	105191
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.004	inside	Integron	-	-	36123..135858	99735
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 IS/Tn TA000174, TA000175, TA000176, TA010030 416601..417581 0	flank	IS/Tn	-	-	117072..118052	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-86)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18527.18 Da
• Isoelectric Point: 8.7753

>T95387 WP_000982260.1 NZ_CP026648:c122755-122258 [Vibrio cholerae O1 biovar El Tor]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Nucleotide

• Length: 498 bp

>T95387 NZ_CP026648:c122755-122258 [Vibrio cholerae O1 biovar El Tor]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9683.22 Da
• Isoelectric Point: 6.2988

>AT95387 WP_000246253.1 NZ_CP026648:c123024-122752 [Vibrio cholerae O1 biovar El Tor]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Nucleotide

• Length: 273 bp

>AT95387 NZ_CP026648:c123024-122752 [Vibrio cholerae O1 biovar El Tor]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Structures

Toxin

• AlphaFold DB: A0A0Q0KGB1

Antitoxin

• AlphaFold DB: A0A0F2IC79