Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 122258..123024 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag C4E16_RS15195 Protein ID WP_000982260.1
Coordinates 122258..122755 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag C4E16_RS15200 Protein ID WP_000246253.1
Coordinates 122752..123024 (-) Length 91 a.a.

Genomic Context

C4E16_RS15145C4E16_RS15150C4E16_RS15155C4E16_RS15160C4E16_RS15165C4E16_RS15170C4E16_RS15175C4E16_RS15180C4E16_RS15185C4E16_RS15205C4E16_RS15210C4E16_RS15215C4E16_RS19585C4E16_RS15225C4E16_RS15235C4E16_RS15240C4E16_RS15250C4E16_RS15195C4E16_RS15200
Location: 118120..118426 (307 bp)
Type: Others
Protein ID: Protein_182
Location: 118563..119255 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 119255..119656 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 119626..119769 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 119844..120257 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 120471..120722 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 120712..120999 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 121127..121582 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 121904..122056 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 123255..123923 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 124075..124362 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 124503..124874 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 124941..125366 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 125363..125896 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 126098..126355 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 126343..126645 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 126879..127796 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 122258..122755 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 122752..123024 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4E16_RS15145118120..118426+307Protein_182CatB-related O-acetyltransferase-
C4E16_RS15150118563..119255+693WP_001047169.1GNAT family N-acetyltransferase-
C4E16_RS15155119255..119656+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
C4E16_RS15160119626..119769+144WP_071908341.1DUF3265 domain-containing protein-
C4E16_RS15165119844..120257+414WP_000049417.1VOC family protein-
C4E16_RS15170120471..120722+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
C4E16_RS15175120712..120999+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
C4E16_RS15180121127..121582+456WP_001245327.1GNAT family N-acetyltransferase-
C4E16_RS15185121904..122056+153WP_001884520.1DUF645 family protein-
C4E16_RS15195122258..122755-498WP_000982260.1GNAT family N-acetyltransferaseToxin
C4E16_RS15200122752..123024-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
C4E16_RS15205123255..123923+669WP_000043871.1hypothetical protein-
C4E16_RS15210124075..124362+288WP_000426470.1hypothetical protein-
C4E16_RS15215124503..124874+372WP_001164080.1nucleotide pyrophosphohydrolase-
C4E16_RS19585124941..125366+426WP_001882332.1DUF1778 domain-containing protein-
C4E16_RS15225125363..125896+534WP_000118351.1GNAT family N-acetyltransferase-
C4E16_RS15235126098..126355+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
C4E16_RS15240126343..126645+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
C4E16_RS15250126879..127796+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31043..136234105191
insideIntegron--36123..13585899735
flankIS/Tn--117072..118052980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T95387 WP_000982260.1 NZ_CP026648:c122755-122258 [Vibrio cholerae O1 biovar El Tor]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T95387 NZ_CP026648:c122755-122258 [Vibrio cholerae O1 biovar El Tor]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT95387 WP_000246253.1 NZ_CP026648:c123024-122752 [Vibrio cholerae O1 biovar El Tor]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT95387 NZ_CP026648:c123024-122752 [Vibrio cholerae O1 biovar El Tor]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References