198984

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 365762..366340 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag J9265_RS15550 Protein ID WP_001180243.1
Coordinates 365762..366079 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag J9265_RS15555 Protein ID WP_000557292.1
Coordinates 366098..366340 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9265_RS15505 (J9265_15505) 360992..361348 + 357 WP_001094969.1 DUF6404 family protein -
J9265_RS19065 361447..361590 + 144 Protein_357 acetyltransferase -
J9265_RS15510 (J9265_15510) 361713..361832 + 120 WP_001900954.1 DUF645 family protein -
J9265_RS15515 (J9265_15515) 362048..362404 + 357 WP_001094970.1 DUF6404 family protein -
J9265_RS15520 (J9265_15520) 362548..363084 + 537 WP_000644491.1 nucleotidyltransferase family protein -
J9265_RS19070 363435..363497 + 63 Protein_361 DUF645 family protein -
J9265_RS19075 363487..363597 + 111 WP_223804330.1 Tfp pilus assembly protein -
J9265_RS15530 (J9265_15530) 363756..364181 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
J9265_RS15535 (J9265_15535) 364330..364677 + 348 WP_000933409.1 hypothetical protein -
J9265_RS15540 (J9265_15540) 364824..365117 + 294 WP_125460920.1 hypothetical protein -
J9265_RS19080 365180..365355 + 176 Protein_366 acetyltransferase -
J9265_RS19085 365416..365568 + 153 Protein_367 DUF645 family protein -
J9265_RS15550 (J9265_15550) 365762..366079 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9265_RS15555 (J9265_15555) 366098..366340 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J9265_RS15560 (J9265_15560) 366582..367091 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
J9265_RS15565 (J9265_15565) 367148..367801 + 654 WP_000226874.1 hypothetical protein -
J9265_RS19090 367890..368099 + 210 WP_001900246.1 DUF3709 domain-containing protein -
J9265_RS15570 (J9265_15570) 368111..368329 + 219 WP_001917086.1 DUF3709 domain-containing protein -
J9265_RS19095 368518..368711 + 194 Protein_374 hypothetical protein -
J9265_RS15575 (J9265_15575) 368732..368965 + 234 WP_032482776.1 DUF3709 domain-containing protein -
J9265_RS15580 (J9265_15580) 369390..369570 + 181 Protein_376 DUF645 family protein -
J9265_RS19100 369683..369796 + 114 WP_001894955.1 hypothetical protein -
J9265_RS15585 (J9265_15585) 369837..370124 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
J9265_RS15590 (J9265_15590) 370135..370452 + 318 WP_001232701.1 HigA family addiction module antitoxin -
J9265_RS15595 (J9265_15595) 370449..370559 + 111 WP_134814058.1 DUF3265 domain-containing protein -
J9265_RS19105 370598..370708 + 111 Protein_381 acetyltransferase -
J9265_RS15600 (J9265_15600) 370736..370861 + 126 WP_001944767.1 DUF645 family protein -
J9265_RS19110 370824..370940 + 117 WP_001889170.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T198984 WP_001180243.1 NZ_CP072848:c366079-365762 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T198984 NZ_CP097079:c5144926-5144543 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT198984 WP_000557292.1 NZ_CP072848:c366340-366098 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT198984 NZ_CP097079:c5145168-5144926 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References