Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 337517..338301 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ81_RS15875 Protein ID WP_001114075.1
Coordinates 337517..337786 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID C3LUY7
Locus tag ASZ81_RS15880 Protein ID WP_000921692.1
Coordinates 337780..338301 (+) Length 174 a.a.

Genomic Context

ASZ81_RS15830ASZ81_RS20835ASZ81_RS20915ASZ81_RS20415ASZ81_RS15855ASZ81_RS15865ASZ81_RS15875ASZ81_RS15880ASZ81_RS20435ASZ81_RS15885ASZ81_RS15890ASZ81_RS20440ASZ81_RS15895ASZ81_RS15905ASZ81_RS15910ASZ81_RS15915ASZ81_RS15920ASZ81_RS15815ASZ81_RS15820
Location: 333884..333961 (78 bp)
Type: Others
Protein ID: WP_071908337.1
Location: 333965..333991 (27 bp)
Type: Others
Protein ID: Protein_298
Location: 334577..334720 (144 bp)
Type: Others
Protein ID: WP_001900215.1
Location: 334814..334993 (180 bp)
Type: Others
Protein ID: Protein_300
Location: 335211..335639 (429 bp)
Type: Others
Protein ID: WP_000620002.1
Location: 336227..336709 (483 bp)
Type: Others
Protein ID: WP_000422940.1
Location: 337517..337786 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 337780..338301 (522 bp)
Type: Antitoxin
Protein ID: WP_000921692.1
Location: 338358..338471 (114 bp)
Type: Others
Protein ID: WP_001894981.1
Location: 338440..339276 (837 bp)
Type: Others
Protein ID: WP_000242986.1
Location: 339441..340079 (639 bp)
Type: Others
Protein ID: WP_000230118.1
Location: 340169..340329 (161 bp)
Type: Others
Protein ID: Protein_308
Location: 340350..340571 (222 bp)
Type: Others
Protein ID: WP_012705854.1
Location: 340891..341211 (321 bp)
Type: Others
Protein ID: WP_001909340.1
Location: 341208..341741 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 341979..342257 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 342658..342882 (225 bp)
Type: Others
Protein ID: WP_001894423.1
Location: 332927..333226 (300 bp)
Type: Others
Protein ID: WP_000802136.1
Location: 333223..333465 (243 bp)
Type: Others
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS15815332927..333226-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ81_RS15820333223..333465-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxin-
ASZ81_RS15830333884..333961+78WP_071908337.1DUF645 family protein-
ASZ81_RS20835333965..333991+27Protein_298hypothetical protein-
ASZ81_RS20915334577..334720+144WP_001900215.1hypothetical protein-
ASZ81_RS20415334814..334993+180Protein_300DUF645 family protein-
ASZ81_RS15855335211..335639+429WP_000620002.1N-acetyltransferase-
ASZ81_RS15865336227..336709+483WP_000422940.1GNAT family N-acetyltransferase-
ASZ81_RS15875337517..337786+270WP_001114075.1DUF4160 domain-containing proteinToxin
ASZ81_RS15880337780..338301+522WP_000921692.1DUF2442 domain-containing proteinAntitoxin
ASZ81_RS20435338358..338471+114WP_001894981.1hypothetical protein-
ASZ81_RS15885338440..339276+837WP_000242986.1hypothetical protein-
ASZ81_RS15890339441..340079+639WP_000230118.1HD domain-containing protein-
ASZ81_RS20440340169..340329+161Protein_308DUF3709 domain-containing protein-
ASZ81_RS15895340350..340571+222WP_012705854.1DUF3709 domain-containing protein-
ASZ81_RS15905340891..341211+321WP_001909340.1DUF1778 domain-containing protein-
ASZ81_RS15910341208..341741+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ81_RS15915341979..342257+279WP_000280324.1DUF3709 domain-containing protein-
ASZ81_RS15920342658..342882+225WP_001894423.1DUF3709 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58261 WP_001114075.1 NZ_CP013306:337517-337786 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58261 NZ_CP013306:337517-337786 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19439.04 Da        Isoelectric Point: 6.7342

>AT58261 WP_000921692.1 NZ_CP013306:337780-338301 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58261 NZ_CP013306:337780-338301 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBC3LUY7

References