Detailed information of TA system TA058261

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 337517..338301
• Replicon: chromosome
• Accession: NZ_CP013306
• Organism: Vibrio cholerae strain CRC1106

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: ASZ81_RS15875
• Protein ID: WP_001114075.1
• Coordinates: 337517..337786 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: C3LUY7
• Locus tag: ASZ81_RS15880
• Protein ID: WP_000921692.1
• Coordinates: 337780..338301 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ81_RS15815	332927..333226	-	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ASZ81_RS15820	333223..333465	-	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	-
ASZ81_RS15830	333884..333961	+	78	WP_071908337.1	DUF645 family protein	-
ASZ81_RS20835	333965..333991	+	27	Protein_298	hypothetical protein	-
ASZ81_RS20915	334577..334720	+	144	WP_001900215.1	hypothetical protein	-
ASZ81_RS20415	334814..334993	+	180	Protein_300	DUF645 family protein	-
ASZ81_RS15855	335211..335639	+	429	WP_000620002.1	N-acetyltransferase	-
ASZ81_RS15865	336227..336709	+	483	WP_000422940.1	GNAT family N-acetyltransferase	-
ASZ81_RS15875	337517..337786	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
ASZ81_RS15880	337780..338301	+	522	WP_000921692.1	DUF2442 domain-containing protein	Antitoxin
ASZ81_RS20435	338358..338471	+	114	WP_001894981.1	hypothetical protein	-
ASZ81_RS15885	338440..339276	+	837	WP_000242986.1	hypothetical protein	-
ASZ81_RS15890	339441..340079	+	639	WP_000230118.1	HD domain-containing protein	-
ASZ81_RS20440	340169..340329	+	161	Protein_308	DUF3709 domain-containing protein	-
ASZ81_RS15895	340350..340571	+	222	WP_012705854.1	DUF3709 domain-containing protein	-
ASZ81_RS15905	340891..341211	+	321	WP_001909340.1	DUF1778 domain-containing protein	-
ASZ81_RS15910	341208..341741	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
ASZ81_RS15915	341979..342257	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ81_RS15920	342658..342882	+	225	WP_001894423.1	DUF3709 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304741..463550	158809
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.006	inside	Integron	-	-	309821..463174	153353

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T58261 WP_001114075.1 NZ_CP013306:337517-337786 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T58261 NZ_CP013306:337517-337786 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19439.04 Da
• Isoelectric Point: 6.7342

>AT58261 WP_000921692.1 NZ_CP013306:337780-338301 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT58261 NZ_CP013306:337780-338301 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: C3LUY7