Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 422186..422952 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GTF73_RS16085 Protein ID WP_000982260.1
Coordinates 422186..422683 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GTF73_RS16090 Protein ID WP_000246253.1
Coordinates 422680..422952 (-) Length 91 a.a.

Genomic Context

GTF73_RS16040GTF73_RS16045GTF73_RS16050GTF73_RS16055GTF73_RS16060GTF73_RS16065GTF73_RS16070GTF73_RS16075GTF73_RS16080GTF73_RS16095GTF73_RS16100GTF73_RS16105GTF73_RS16110GTF73_RS16115GTF73_RS16120GTF73_RS16125GTF73_RS16130GTF73_RS16085GTF73_RS16090
Location: 418048..418320 (273 bp)
Type: Others
Protein ID: Protein_451
Location: 418491..419183 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 419183..419584 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 419554..419697 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419772..420185 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 420399..420650 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420640..420927 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 421055..421510 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421832..421984 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 423183..423851 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424003..424290 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424431..424802 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424869..425294 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 425291..425824 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 426026..426283 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 426271..426573 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 426807..427724 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 422186..422683 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 422680..422952 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF73_RS16040418048..418320+273Protein_451CatB-related O-acetyltransferase-
GTF73_RS16045418491..419183+693WP_001047169.1GNAT family N-acetyltransferase-
GTF73_RS16050419183..419584+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
GTF73_RS16055419554..419697+144WP_071908341.1DUF3265 domain-containing protein-
GTF73_RS16060419772..420185+414WP_000049417.1VOC family protein-
GTF73_RS16065420399..420650+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF73_RS16070420640..420927+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF73_RS16075421055..421510+456WP_001245327.1GNAT family N-acetyltransferase-
GTF73_RS16080421832..421984+153WP_001884520.1DUF645 family protein-
GTF73_RS16085422186..422683-498WP_000982260.1GNAT family N-acetyltransferaseToxin
GTF73_RS16090422680..422952-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
GTF73_RS16095423183..423851+669WP_000043871.1hypothetical protein-
GTF73_RS16100424003..424290+288WP_000426470.1hypothetical protein-
GTF73_RS16105424431..424802+372WP_001164080.1nucleotide pyrophosphohydrolase-
GTF73_RS16110424869..425294+426WP_001882332.1DUF1778 domain-containing protein-
GTF73_RS16115425291..425824+534WP_000118351.1GNAT family N-acetyltransferase-
GTF73_RS16120426026..426283+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF73_RS16125426271..426573+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF73_RS16130426807..427724+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306901..436162129261
insideIntegron--311981..435786123805
flankIS/Tn--417000..417980980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145836 WP_000982260.1 NZ_CP047298:c422683-422186 [Vibrio cholerae O1 biovar El Tor]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145836 NZ_CP062702:c702893-702429 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145836 WP_000246253.1 NZ_CP047298:c422952-422680 [Vibrio cholerae O1 biovar El Tor]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145836 NZ_CP062702:c703228-702893 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References