Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 415657..416750 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag C1H56_RS16730 Protein ID WP_000351248.1
Coordinates 416349..416750 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag C1H56_RS16725 Protein ID WP_001047169.1
Coordinates 415657..416349 (+) Length 231 a.a.

Genomic Context

C1H56_RS16660C1H56_RS20005C1H56_RS16665C1H56_RS16680C1H56_RS16685C1H56_RS16700C1H56_RS16705C1H56_RS16710C1H56_RS19860C1H56_RS16720C1H56_RS16725C1H56_RS16730C1H56_RS16735C1H56_RS16740C1H56_RS16745C1H56_RS16750C1H56_RS16755C1H56_RS16760C1H56_RS16780C1H56_RS16785C1H56_RS16715C1H56_RS16770C1H56_RS16775
Location: 410940..411317 (378 bp)
Type: Others
Protein ID: WP_000411109.1
Location: 411374..411488 (115 bp)
Type: Others
Protein ID: Protein_435
Location: 411437..411718 (282 bp)
Type: Others
Protein ID: WP_001894453.1
Location: 411884..411997 (114 bp)
Type: Others
Protein ID: WP_001889158.1
Location: 411946..412173 (228 bp)
Type: Others
Protein ID: WP_001894457.1
Location: 412514..412846 (333 bp)
Type: Others
Protein ID: WP_000843587.1
Location: 412833..413147 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 413284..413718 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 413886..414041 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 415214..415486 (273 bp)
Type: Others
Protein ID: Protein_444
Location: 415657..416349 (693 bp)
Type: Antitoxin
Protein ID: WP_001047169.1
Location: 416349..416750 (402 bp)
Type: Toxin
Protein ID: WP_000351248.1
Location: 416720..416863 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 416938..417351 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 417565..417816 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 417806..418093 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 418221..418676 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 418998..419150 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 420349..421017 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 421169..421456 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 414166..415146 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 419352..419849 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 419846..420118 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1H56_RS16660410940..411317+378WP_000411109.1hypothetical protein-
C1H56_RS20005411374..411488+115Protein_435acetyltransferase-
C1H56_RS16665411437..411718+282WP_001894453.1DUF1289 domain-containing protein-
C1H56_RS16680411884..411997+114WP_001889158.1hypothetical protein-
C1H56_RS16685411946..412173+228WP_001894457.1DUF1289 domain-containing protein-
C1H56_RS16700412514..412846+333WP_000843587.1type II toxin-antitoxin system RelE/ParE family toxin-
C1H56_RS16705412833..413147+315WP_000071008.1DNA-binding transcriptional regulator-
C1H56_RS16710413284..413718+435WP_000256036.1GNAT family N-acetyltransferase-
C1H56_RS19860413886..414041+156WP_000751734.1hypothetical protein-
C1H56_RS16715414166..415146-981WP_000019370.1IS5-like element ISVch5 family transposase-
C1H56_RS16720415214..415486+273Protein_444CatB-related O-acetyltransferase-
C1H56_RS16725415657..416349+693WP_001047169.1GNAT family N-acetyltransferaseAntitoxin
C1H56_RS16730416349..416750+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxinToxin
C1H56_RS16735416720..416863+144WP_071908341.1DUF3265 domain-containing protein-
C1H56_RS16740416938..417351+414WP_000049417.1VOC family protein-
C1H56_RS16745417565..417816+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
C1H56_RS16750417806..418093+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
C1H56_RS16755418221..418676+456WP_001245327.1GNAT family N-acetyltransferase-
C1H56_RS16760418998..419150+153WP_001884520.1DUF645 family protein-
C1H56_RS16770419352..419849-498WP_000982260.1GNAT family N-acetyltransferase-
C1H56_RS16775419846..420118-273WP_000246253.1DUF1778 domain-containing protein-
C1H56_RS16780420349..421017+669WP_000043871.1hypothetical protein-
C1H56_RS16785421169..421456+288WP_000426470.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304067..433328129261
insideIntegroncatB9-309147..432952123805
flankIS/Tn--414166..415146980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T92512 WP_000351248.1 NZ_CP025937:416349-416750 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T92512 NZ_CP025937:416349-416750 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT92512 WP_001047169.1 NZ_CP025937:415657-416349 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT92512 NZ_CP025937:415657-416349 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0PN34

Antitoxin

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Source
ID
Structure
No matching records found

References