145864

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 322575..323153 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF75_RS15290 Protein ID WP_001180243.1
Coordinates 322575..322892 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF75_RS15295 Protein ID WP_000557292.1
Coordinates 322911..323153 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF75_RS15260 318099..318281 + 183 WP_000923340.1 DUF645 family protein -
GTF75_RS15265 318635..318817 + 183 WP_000923153.1 DUF645 family protein -
GTF75_RS15270 319012..319689 + 678 WP_000254617.1 HNH endonuclease -
GTF75_RS15275 319851..321059 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
GTF75_RS15280 321221..321925 + 705 WP_000087610.1 HNH endonuclease -
GTF75_RS15285 322083..322421 + 339 WP_000713853.1 hypothetical protein -
GTF75_RS15290 322575..322892 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF75_RS15295 322911..323153 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF75_RS15300 323397..323783 + 387 WP_001015867.1 NUDIX hydrolase -
GTF75_RS15305 323840..323953 + 114 WP_001900214.1 hypothetical protein -
GTF75_RS15310 323902..324183 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GTF75_RS15315 324159..324317 - 159 WP_001886450.1 DUF1196 family protein -
GTF75_RS15320 324441..324977 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF75_RS15325 325114..325629 + 516 WP_001201509.1 lipocalin family protein -
GTF75_RS15330 325779..326276 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF75_RS15335 326273..326545 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF75_RS15340 326938..327063 + 126 WP_001900195.1 DUF645 family protein -
GTF75_RS15345 327079..327117 + 39 WP_106019118.1 hypothetical protein -
GTF75_RS15350 327313..327759 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305935..411136 105201
inside Integron - - 311015..410760 99745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145864 WP_001180243.1 NZ_CP047302:c322892-322575 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145864 NZ_CP062705:409381-409908 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145864 WP_000557292.1 NZ_CP047302:c323153-322911 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145864 NZ_CP062705:409108-409374 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References