Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 422775..423541 Replicon chromosome
Accession NZ_CP047304
Organism Vibrio cholerae O1 biovar El Tor strain E7946

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GTF74_RS16075 Protein ID WP_000982260.1
Coordinates 422775..423272 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GTF74_RS16080 Protein ID WP_000246253.1
Coordinates 423269..423541 (-) Length 91 a.a.

Genomic Context

GTF74_RS16030GTF74_RS16035GTF74_RS16040GTF74_RS16045GTF74_RS16050GTF74_RS16055GTF74_RS16060GTF74_RS16065GTF74_RS16070GTF74_RS16085GTF74_RS16090GTF74_RS16095GTF74_RS16100GTF74_RS16105GTF74_RS16110GTF74_RS16115GTF74_RS16120GTF74_RS16075GTF74_RS16080
Location: 418637..418909 (273 bp)
Type: Others
Protein ID: Protein_452
Location: 419080..419772 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 419772..420173 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 420143..420286 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 420361..420774 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 420988..421239 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 421229..421516 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 421644..422099 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 422421..422573 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 423772..424440 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424592..424879 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 425020..425391 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 425458..425883 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 425880..426413 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 426615..426872 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 426860..427162 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 427396..428313 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 422775..423272 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 423269..423541 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GTF74_RS16030418637..418909+273Protein_452CatB-related O-acetyltransferase-
GTF74_RS16035419080..419772+693WP_001047169.1GNAT family N-acetyltransferase-
GTF74_RS16040419772..420173+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
GTF74_RS16045420143..420286+144WP_071908341.1DUF3265 domain-containing protein-
GTF74_RS16050420361..420774+414WP_000049417.1VOC family protein-
GTF74_RS16055420988..421239+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF74_RS16060421229..421516+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF74_RS16065421644..422099+456WP_001245327.1GNAT family N-acetyltransferase-
GTF74_RS16070422421..422573+153WP_001884520.1DUF645 family protein-
GTF74_RS16075422775..423272-498WP_000982260.1GNAT family N-acetyltransferaseToxin
GTF74_RS16080423269..423541-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
GTF74_RS16085423772..424440+669WP_000043871.1hypothetical protein-
GTF74_RS16090424592..424879+288WP_000426470.1hypothetical protein-
GTF74_RS16095425020..425391+372WP_001164080.1nucleotide pyrophosphohydrolase-
GTF74_RS16100425458..425883+426WP_001882332.1DUF1778 domain-containing protein-
GTF74_RS16105425880..426413+534WP_000118351.1GNAT family N-acetyltransferase-
GTF74_RS16110426615..426872+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
GTF74_RS16115426860..427162+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
GTF74_RS16120427396..428313+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-307032..436751129719
insideIntegron--312112..436375124263
flankIS/Tn--417589..418569980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145896 WP_000982260.1 NZ_CP047304:c423272-422775 [Vibrio cholerae O1 biovar El Tor]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145896 NZ_CP062708:432920-433894 [Escherichia coli O157:H7]
GTGGGGCGTGCCGGTCGCGGTATCGATTCTGCTGTTGGCATACTGCTTTGCGGCAGTGAAGACCGTGCTATTCATAAATT
CTTCCGTGAAAGCGCCTTTCCTGCGGAGGCGCAAATTCATGAAATACTCAACGTACTTAGCGTGAATGACGGTCTTACCT
TACGAGGCATTGAACAACGGACGAATCTCCGTTATGGGCAAATAGAAAAAGCACTGAAATTATTGGTAGCTGAAAATCCA
TCGCCTGTGGTGTATACCGAGAAATTATGGCGCAGAACAATTGTCAGTTTTTCTCCTGACCATGAACGAATTAACCATTT
GATGAATCAGAGAAAAAGTGAGCTGGCAGACGTTGAAAGCTATATCACGACCAAGGAGTGCAAAATGCAATTTCTGCGCC
GCGCACTCGATGAGCCAGGTGCCGAACATTGTGGTAAATGTAGCAGTTGTCTTCAGCATCCGTTGTTGTCGCCCGACATT
GATAGCGGCTTACTCCATGCGGCAAACTTATTTATTAAACACGCTGACCTGTCATTAAATCTCAATAAACAGGTGGCAGC
TGGGGCTTTTACGCAATACGGATTTAAAGGGAACTTGCCTGCGAGTTTACAAGGATCTACGGGGCGAATCCTTTCTCGTT
GGGGATATTCCGGGTGGGGAAAGCAGGTAGCACAGGAGAAAAAAACGGGGCGATTCAGTGATGAACTGGTGGAGGCATGT
GCGGAAATGGTTCGCCAACGCTGGAATCCGCATCCTGAACCAACCTGGGTATGCTGCGTTCCTTCATTAAAGCACCTCGA
CCTGGTTCCTGATTTTGAAAGCACCTCGACCTGGTTCCTGATTTTGCCCGGCGACTGGCGGCGAAACTTGGCTTACCTTT
TATTGATGCCATTGAAAAAGTCGTGGACAATCCACCGCAGAAAATGCAGCAAAACCGTTTCCACCAGTGTCAAAATCTCG
ACGGGGCGTTTGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145896 WP_000246253.1 NZ_CP047304:c423541-423269 [Vibrio cholerae O1 biovar El Tor]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145896 NZ_CP062708:433953-435248 [Escherichia coli O157:H7]
ATGGACGCTGACAGTTCTAACAGCACTGTTACGCCAGGCAGGTTGCCCGACGGTTTATCCTCTTGCCCTTGCTTCTACCT
CGGTAAAAAATTGATGAATCTTTCAGCCAATGCACAAGCAACTCTCCTGCTAACCAGCGATTTTTCTCGCGCGGCGGCGA
GTAAGTATAAACCTCTTAGTAATAGTGAATGGGGGAAGTTTGCATTATGGCTGAAGCACCAACGTATCAGTCCCGCCGAG
CTTCTGGTGCCGCAACCGCAAGAGAAACTTACAGGCTGGAGCGATCCGCGTATTTCTCAGGAGCGTATTCTTGGCTTGCT
GGCGCGTGGTCATAGTCTGGCGTTGGCGGTAGATAAGTGGCAACGCGCCGGTTTATGGATCTTAACCCGCGGAGATGCTG
ATTATCCCGTTCGCTTGAAAAACCGATTGCGAACGGATGCACCTCCCGTTTTATTTGGCTGCGGGAATAAAGCATTACTG
CAAGCGGAAGGTATGGCGATTGTTGGCTCGCGAGATGCTCCGACTGACGATTTGCGCTATACCCAACAACTGGCCGCGAA
ACTGGCCCAACAGGGGATTTGCGTTATCTCTGGTGGTGCGCGAGGTATTGATGAATGTGCAATGGCGTCGGCACTGGAGG
CCGGGGGAACTGCCGTTGGCGTATTAGCTGATAGCTTGTTAAAAACGAGTACGTTAGTGAAATGGCGTGAAGGGCTTATA
GCAGGCAACCTGGTGTTGATTTCGCCGTTTTACCCAGAGGTACGTTTCACCGTCGGCAATGCGATGGCGCGAAATAAATA
TATTTATTGCCTTGCTGAAAGCGCAATGGTTGTACGTGCGGGAATGACCGGTGGAACGATAACCGGGGCGATGGAGGCAT
TAAAACATCAGTGGCTGCCTGTGCAGGTTAAACCAAATCAGGATATGCAATCAGCCAATTCACGATTAGTAGAAAATGGG
GCGTCATGGAGTGCTGAACAGGCTGAGAATGTGACGATCAGACTGCCAGACGTTCCTGGGCTGATGTATGACAGAGCACT
CCGTAACGCTCAACCAGAACTGTTTTCGCTGCATGAAGATGACGCAAATTACGCAGTAATGCCCGCGTATACGCCTGTCG
ATTTTTATCAACTCTTTGTGGCGGAACTGGCGATCCTTGCAAAGGAATCGATAAGTATTGAAAGGCTGGCGTCTTGTACT
GGTTTAACCATCGAACAAATTAGTGTGTGGCTGAACCGCGCAGAAGAAGAGGGAAGGGTTATCCGATTGGGCGAAGGTCA
TTATCAGTTCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References