58364

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 452701..453229 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag ASZ79_RS16920 Protein ID WP_000221354.1
Coordinates 452942..453229 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag ASZ79_RS16915 Protein ID WP_001250179.1
Coordinates 452701..452952 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ79_RS16865 447969..448283 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
ASZ79_RS16870 448420..448854 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
ASZ79_RS20835 449022..449177 + 156 WP_000751734.1 hypothetical protein -
ASZ79_RS16885 449302..450282 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
ASZ79_RS16890 450350..450656 + 307 Protein_499 CatB-related O-acetyltransferase -
ASZ79_RS16895 450793..451485 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
ASZ79_RS16900 451485..451886 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
ASZ79_RS20750 451856..451999 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ASZ79_RS16910 452074..452487 + 414 WP_000049417.1 VOC family protein -
ASZ79_RS16915 452701..452952 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ79_RS16920 452942..453229 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ79_RS16925 453357..453812 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ79_RS16935 454134..454286 + 153 WP_001884520.1 DUF645 family protein -
ASZ79_RS16940 454488..454985 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ79_RS16945 454982..455254 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ79_RS16950 455485..456153 + 669 WP_000043871.1 hypothetical protein -
ASZ79_RS16955 456305..456592 + 288 WP_000426470.1 hypothetical protein -
ASZ79_RS16960 456733..457104 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
ASZ79_RS16965 457171..457596 + 426 WP_001882332.1 DUF1778 domain-containing protein -
ASZ79_RS16970 457593..458126 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..468464 163764
inside Integron - - 309780..468088 158308
flank IS/Tn - - 449302..450282 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T58364 WP_000221354.1 NZ_CP013314:452942-453229 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T58364 NZ_CP013314:452942-453229 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT58364 WP_001250179.1 NZ_CP013314:452701-452952 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT58364 NZ_CP013314:452701-452952 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References