Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 465996..466524 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag IT766_RS16090 Protein ID WP_000221352.1
Coordinates 465996..466286 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag IT766_RS16095 Protein ID WP_000213183.1
Coordinates 466276..466524 (-) Length 83 a.a.

Genomic Context

IT766_RS16050IT766_RS16055IT766_RS16060IT766_RS16065IT766_RS16070IT766_RS16075IT766_RS16080IT766_RS16085IT766_RS16100IT766_RS16105IT766_RS16110IT766_RS16115IT766_RS16120IT766_RS16125IT766_RS16090IT766_RS16095IT766_RS16130
Location: 461553..461678 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 461694..461732 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 461945..462949 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 463102..463548 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 463668..464597 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 464594..464704 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 464732..465208 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 465345..465860 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 467095..467748 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 468020..468445 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 468653..469048 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 469199..469729 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 469867..470367 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 470523..470921 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 465996..466286 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 466276..466524 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 471021..471485 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IT766_RS16050461553..461678+126WP_001944767.1DUF645 family protein-
IT766_RS16055461694..461732+39WP_106019119.1hypothetical protein-
IT766_RS16060461945..462949+1005WP_000964925.1LD-carboxypeptidase-
IT766_RS16065463102..463548+447WP_000128977.1hypothetical protein-
IT766_RS16070463668..464597+930WP_000335802.1hypothetical protein-
IT766_RS16075464594..464704+111WP_071917832.1DUF3265 domain-containing protein-
IT766_RS16080464732..465208+477WP_001047180.1GNAT family N-acetyltransferase-
IT766_RS16085465345..465860+516WP_001201528.1lipocalin family protein-
IT766_RS16090465996..466286-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IT766_RS16095466276..466524-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
IT766_RS16100467095..467748+654WP_000036957.1site-specific DNA-methyltransferase-
IT766_RS16105468020..468445+426WP_000415748.1hypothetical protein-
IT766_RS16110468653..469048+396WP_000649527.1DUF3465 domain-containing protein-
IT766_RS16115469199..469729+531WP_000415563.1hypothetical protein-
IT766_RS16120469867..470367+501WP_000789723.1hypothetical protein-
IT766_RS16125470523..470921+399WP_001882293.1hypothetical protein-
IT766_RS16130471021..471485-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-373204..502464129260
insideIntegron--378284..502088123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T180873 WP_000221352.1 NZ_CP064351:c466286-465996 [Vibrio cholerae C6706]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T180873 NZ_CP085767:c2079908-2079558 [Enterobacter hormaechei]
ATGTGGACGGTACTGTTTAGTAAGGTATTCGAGCAATGGTTGCTTGAACAGGAAGATGGGTTGCAGGAAAAGGTATTGGC
AGACCTGTTAAATCTACAGAATTATGGACCGCGTCTTCCTCGTCCCTATGCGGATACCGTTAAAGGGTCACAGTATAAGA
ATATGAAAGAGTTACGTATTCAATATGCGGGTCGCCCGGTTCGTGCGTTCTTCGCGTTTGATCCTGTACGTCAGGCCATT
GTGCTTTGCGCGGGCGATAAGCGTAATGACAAAACCTTTTATGAAAAACTGATTCGCATTGCAGATGCCGAATTCACCCT
TCATCTGACAAGCCTGGAGGCAGCCAAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT180873 WP_000213183.1 NZ_CP064351:c466524-466276 [Vibrio cholerae C6706]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT180873 NZ_CP085767:c2079561-2079262 [Enterobacter hormaechei]
GTGAAAACCTTAAATGAAGTGATTGCGTCACGCTCACCGGAAAGCCAACAGCGCATTCAGGAGATGGCAGAGGAAATGTT
CCTCGAAACCGGTCTGCAACTTCTGCGTGAAGAGCTCCAGCTTTCGCAAAAACATGTCGCCGATCTTATGGGCGTAAGTC
AACCTGCGGTAACACAGCTGGAGCAGCGTGGAAACGATCTTAAGATTGCTACGCTTAAGCGTTACATCGAAGCGATGGGC
GGAAAACTTAGCATTAACGTGGAACTTCCCACTGGCAAGCGGGTTGCGTTTCATCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References