180873

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 465996..466524 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag IT766_RS16090 Protein ID WP_000221352.1
Coordinates 465996..466286 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag IT766_RS16095 Protein ID WP_000213183.1
Coordinates 466276..466524 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT766_RS16050 461553..461678 + 126 WP_001944767.1 DUF645 family protein -
IT766_RS16055 461694..461732 + 39 WP_106019119.1 hypothetical protein -
IT766_RS16060 461945..462949 + 1005 WP_000964925.1 LD-carboxypeptidase -
IT766_RS16065 463102..463548 + 447 WP_000128977.1 hypothetical protein -
IT766_RS16070 463668..464597 + 930 WP_000335802.1 hypothetical protein -
IT766_RS16075 464594..464704 + 111 WP_071917832.1 DUF3265 domain-containing protein -
IT766_RS16080 464732..465208 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
IT766_RS16085 465345..465860 + 516 WP_001201528.1 lipocalin family protein -
IT766_RS16090 465996..466286 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IT766_RS16095 466276..466524 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IT766_RS16100 467095..467748 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
IT766_RS16105 468020..468445 + 426 WP_000415748.1 hypothetical protein -
IT766_RS16110 468653..469048 + 396 WP_000649527.1 DUF3465 domain-containing protein -
IT766_RS16115 469199..469729 + 531 WP_000415563.1 hypothetical protein -
IT766_RS16120 469867..470367 + 501 WP_000789723.1 hypothetical protein -
IT766_RS16125 470523..470921 + 399 WP_001882293.1 hypothetical protein -
IT766_RS16130 471021..471485 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 373204..502464 129260
inside Integron - - 378284..502088 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T180873 WP_000221352.1 NZ_CP064351:c466286-465996 [Vibrio cholerae C6706]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T180873 NZ_CP085767:c2079908-2079558 [Enterobacter hormaechei]
ATGTGGACGGTACTGTTTAGTAAGGTATTCGAGCAATGGTTGCTTGAACAGGAAGATGGGTTGCAGGAAAAGGTATTGGC
AGACCTGTTAAATCTACAGAATTATGGACCGCGTCTTCCTCGTCCCTATGCGGATACCGTTAAAGGGTCACAGTATAAGA
ATATGAAAGAGTTACGTATTCAATATGCGGGTCGCCCGGTTCGTGCGTTCTTCGCGTTTGATCCTGTACGTCAGGCCATT
GTGCTTTGCGCGGGCGATAAGCGTAATGACAAAACCTTTTATGAAAAACTGATTCGCATTGCAGATGCCGAATTCACCCT
TCATCTGACAAGCCTGGAGGCAGCCAAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT180873 WP_000213183.1 NZ_CP064351:c466524-466276 [Vibrio cholerae C6706]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT180873 NZ_CP085767:c2079561-2079262 [Enterobacter hormaechei]
GTGAAAACCTTAAATGAAGTGATTGCGTCACGCTCACCGGAAAGCCAACAGCGCATTCAGGAGATGGCAGAGGAAATGTT
CCTCGAAACCGGTCTGCAACTTCTGCGTGAAGAGCTCCAGCTTTCGCAAAAACATGTCGCCGATCTTATGGGCGTAAGTC
AACCTGCGGTAACACAGCTGGAGCAGCGTGGAAACGATCTTAAGATTGCTACGCTTAAGCGTTACATCGAAGCGATGGGC
GGAAAACTTAGCATTAACGTGGAACTTCCCACTGGCAAGCGGGTTGCGTTTCATCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References