145858

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 429156..429703 Replicon chromosome
Accession NZ_CP047300
Organism Vibrio cholerae O1 biovar El Tor strain P27459

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag GTF71_RS15810 Protein ID WP_000229317.1
Coordinates 429401..429703 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GTF71_RS15805 Protein ID WP_000861987.1
Coordinates 429156..429413 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF71_RS15760 424185..424640 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GTF71_RS15765 424962..425114 + 153 WP_001884520.1 DUF645 family protein -
GTF71_RS15770 425316..425813 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF71_RS15775 425810..426082 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF71_RS15780 426313..426981 + 669 WP_000043871.1 hypothetical protein -
GTF71_RS15785 427133..427420 + 288 WP_000426470.1 hypothetical protein -
GTF71_RS15790 427561..427932 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GTF71_RS15795 427999..428424 + 426 WP_001882332.1 DUF1778 domain-containing protein -
GTF71_RS15800 428421..428954 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
GTF71_RS15805 429156..429413 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF71_RS15810 429401..429703 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF71_RS15815 429937..430854 + 918 WP_000186333.1 alpha/beta hydrolase -
GTF71_RS15820 431011..431400 + 390 WP_001081302.1 hypothetical protein -
GTF71_RS15825 431536..431745 + 210 Protein_475 GNAT family N-acetyltransferase -
GTF71_RS15830 431864..432301 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GTF71_RS15835 432365..432583 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GTF71_RS15840 432758..433630 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GTF71_RS15845 433780..434379 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GTF71_RS15850 434436..434540 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306926..439292 132366
inside Integron - - 312006..438916 126910
flank IS/Tn - - 431864..432301 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T145858 WP_000229317.1 NZ_CP047300:429401-429703 [Vibrio cholerae O1 biovar El Tor]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145858 NZ_CP062703:2068-2343 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145858 WP_000861987.1 NZ_CP047300:429156-429413 [Vibrio cholerae O1 biovar El Tor]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145858 NZ_CP062703:1784-2068 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References