145397

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 349542..350080 Replicon chromosome
Accession NZ_CP047060
Organism Vibrio cholerae isolate CTMA_1441

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GQX72_RS15470 Protein ID WP_000802136.1
Coordinates 349542..349841 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GQX72_RS15475 Protein ID WP_001107719.1
Coordinates 349838..350080 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQX72_RS15425 345477..345659 + 183 WP_000923182.1 DUF645 family protein -
GQX72_RS15430 345859..346332 + 474 WP_001161076.1 GrpB family protein -
GQX72_RS15435 346347..346439 + 93 WP_014378730.1 DUF3265 domain-containing protein -
GQX72_RS15440 346481..347107 + 627 WP_000365424.1 LysE family translocator -
GQX72_RS15445 347230..347928 + 699 WP_001890502.1 hypothetical protein -
GQX72_RS15450 347938..348048 + 111 WP_079857360.1 DUF3265 domain-containing protein -
GQX72_RS15460 348626..348805 + 180 WP_001883058.1 DUF645 family protein -
GQX72_RS15465 349019..349414 + 396 WP_000870857.1 DUF3465 domain-containing protein -
GQX72_RS15470 349542..349841 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GQX72_RS15475 349838..350080 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GQX72_RS15485 350309..350887 + 579 WP_000110120.1 hypothetical protein -
GQX72_RS15490 350909..351001 + 93 WP_014164112.1 DUF3265 domain-containing protein -
GQX72_RS15500 351425..352108 + 684 WP_000877436.1 hypothetical protein -
GQX72_RS15505 352322..352588 + 267 WP_000937852.1 hypothetical protein -
GQX72_RS15510 352743..353342 + 600 WP_000429495.1 hypothetical protein -
GQX72_RS15515 353623..354558 + 936 WP_000051985.1 restriction endonuclease -
GQX72_RS15520 354524..354664 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305960..411159 105199
inside Integron - - 311040..410783 99743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T145397 WP_000802136.1 NZ_CP047060:c349841-349542 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145397 NZ_CP062372:c2356190-2355924 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT145397 WP_001107719.1 NZ_CP047060:c350080-349838 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145397 NZ_CP062372:c2356441-2356190 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References