211910

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 945890..946656 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag K1T75_RS17890 Protein ID WP_000982260.1
Coordinates 946159..946656 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag K1T75_RS17885 Protein ID WP_000246253.1
Coordinates 945890..946162 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS17845 941118..942035 - 918 WP_000186333.1 alpha/beta hydrolase -
K1T75_RS17850 942269..942571 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
K1T75_RS17855 942559..942816 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K1T75_RS18835 942898..943008 - 111 WP_086010065.1 DUF3265 domain-containing protein -
K1T75_RS17860 943018..943551 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
K1T75_RS18840 943548..943817 - 270 WP_000179600.1 DUF1778 domain-containing protein -
K1T75_RS17870 944040..944411 - 372 WP_001164080.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
K1T75_RS17875 944552..944839 - 288 WP_000426470.1 hypothetical protein -
K1T75_RS17880 944991..945659 - 669 WP_000043871.1 hypothetical protein -
K1T75_RS18845 945676..945738 - 63 Protein_821 acetyltransferase -
K1T75_RS17885 945890..946162 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
K1T75_RS17890 946159..946656 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
K1T75_RS18850 946673..946741 - 69 Protein_824 acetyltransferase -
K1T75_RS17895 946858..946962 - 105 WP_228840819.1 DUF645 family protein -
K1T75_RS18855 947153..947275 - 123 Protein_826 acetyltransferase -
K1T75_RS17900 947332..947787 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
K1T75_RS17905 947915..948202 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K1T75_RS17910 948192..948443 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K1T75_RS17915 948657..949070 - 414 WP_000049417.1 VOC family protein -
K1T75_RS18860 949145..949255 - 111 WP_082798255.1 DUF3265 domain-containing protein -
K1T75_RS17920 949258..949659 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
K1T75_RS18865 949659..949829 - 171 WP_001080654.1 hypothetical protein -
K1T75_RS18870 949953..950351 - 399 Protein_834 GNAT family N-acetyltransferase -
K1T75_RS17930 950488..950794 - 307 Protein_835 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736
flank IS/Tn - - 950862..951842 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T211910 WP_000982260.1 NZ_CP080466:946159-946656 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T211910 NZ_CP106838:4241481-4241584 [Klebsiella michiganensis]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT211910 WP_000246253.1 NZ_CP080466:945890-946162 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT211910 NZ_CP106838:c4241591-4241423 [Klebsiella michiganensis]
AACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGCGACAAAAGTG
GACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References