Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 945890..946656 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag K1T75_RS17890 Protein ID WP_000982260.1
Coordinates 946159..946656 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag K1T75_RS17885 Protein ID WP_000246253.1
Coordinates 945890..946162 (+) Length 91 a.a.

Genomic Context

K1T75_RS17885K1T75_RS17890K1T75_RS17845K1T75_RS17850K1T75_RS17855K1T75_RS18835K1T75_RS17860K1T75_RS18840K1T75_RS17870K1T75_RS17875K1T75_RS17880K1T75_RS18845K1T75_RS18850K1T75_RS17895K1T75_RS18855K1T75_RS17900K1T75_RS17905K1T75_RS17910K1T75_RS17915K1T75_RS18860K1T75_RS17920K1T75_RS18865K1T75_RS18870K1T75_RS17930
Location: 945890..946162 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 946159..946656 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 941118..942035 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 942269..942571 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 942559..942816 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 942898..943008 (111 bp)
Type: Others
Protein ID: WP_086010065.1
Location: 943018..943551 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 943548..943817 (270 bp)
Type: Others
Protein ID: WP_000179600.1
Location: 944040..944411 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 944552..944839 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 944991..945659 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 945676..945738 (63 bp)
Type: Others
Protein ID: Protein_821
Location: 946673..946741 (69 bp)
Type: Others
Protein ID: Protein_824
Location: 946858..946962 (105 bp)
Type: Others
Protein ID: WP_228840819.1
Location: 947153..947275 (123 bp)
Type: Others
Protein ID: Protein_826
Location: 947332..947787 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 947915..948202 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 948192..948443 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 948657..949070 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 949145..949255 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 949258..949659 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 949659..949829 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 949953..950351 (399 bp)
Type: Others
Protein ID: Protein_834
Location: 950488..950794 (307 bp)
Type: Others
Protein ID: Protein_835
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K1T75_RS17845941118..942035-918WP_000186333.1alpha/beta hydrolase-
K1T75_RS17850942269..942571-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
K1T75_RS17855942559..942816-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K1T75_RS18835942898..943008-111WP_086010065.1DUF3265 domain-containing protein-
K1T75_RS17860943018..943551-534WP_000118351.1GNAT family N-acetyltransferase-
K1T75_RS18840943548..943817-270WP_000179600.1DUF1778 domain-containing protein-
K1T75_RS17870944040..944411-372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
K1T75_RS17875944552..944839-288WP_000426470.1hypothetical protein-
K1T75_RS17880944991..945659-669WP_000043871.1hypothetical protein-
K1T75_RS18845945676..945738-63Protein_821acetyltransferase-
K1T75_RS17885945890..946162+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
K1T75_RS17890946159..946656+498WP_000982260.1GNAT family N-acetyltransferaseToxin
K1T75_RS18850946673..946741-69Protein_824acetyltransferase-
K1T75_RS17895946858..946962-105WP_228840819.1DUF645 family protein-
K1T75_RS18855947153..947275-123Protein_826acetyltransferase-
K1T75_RS17900947332..947787-456WP_001245327.1GNAT family N-acetyltransferase-
K1T75_RS17905947915..948202-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
K1T75_RS17910948192..948443-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
K1T75_RS17915948657..949070-414WP_000049417.1VOC family protein-
K1T75_RS18860949145..949255-111WP_082798255.1DUF3265 domain-containing protein-
K1T75_RS17920949258..949659-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
K1T75_RS18865949659..949829-171WP_001080654.1hypothetical protein-
K1T75_RS18870949953..950351-399Protein_834GNAT family N-acetyltransferase-
K1T75_RS17930950488..950794-307Protein_835CatB-related O-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932680..1039634106954
insideIntegron--933056..103279299736
flankIS/Tn--950862..951842980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T211910 WP_000982260.1 NZ_CP080466:946159-946656 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T211910 NZ_CP106838:4241481-4241584 [Klebsiella michiganensis]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT211910 WP_000246253.1 NZ_CP080466:945890-946162 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT211910 NZ_CP106838:c4241591-4241423 [Klebsiella michiganensis]
AACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGCGACAAAAGTG
GACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References