Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 141998..142526 Replicon chromosome
Accession NZ_CP033513
Organism Vibrio cholerae strain E4

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag EEL44_RS00715 Protein ID WP_000221354.1
Coordinates 141998..142285 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag EEL44_RS00720 Protein ID WP_001250179.1
Coordinates 142275..142526 (-) Length 84 a.a.

Genomic Context

EEL44_RS00690EEL44_RS00695EEL44_RS00750EEL44_RS00665EEL44_RS00670EEL44_RS00675EEL44_RS00680EEL44_RS00685EEL44_RS00705EEL44_RS00710EEL44_RS00715EEL44_RS00720EEL44_RS00725EEL44_RS00730EEL44_RS00735EEL44_RS00740EEL44_RS00745EEL44_RS20945EEL44_RS00755EEL44_RS00760
Location: 139973..140245 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 140242..140739 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 144945..145925 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 137101..137634 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 137631..138056 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 138123..138494 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 138635..138922 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 139074..139742 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 140941..141093 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 141415..141870 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 141998..142285 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 142275..142526 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 142740..143153 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 143228..143371 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 143341..143742 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 143742..144434 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 144571..144877 (307 bp)
Type: Others
Protein ID: Protein_138
Location: 146050..146205 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 146373..146807 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 146944..147258 (315 bp)
Type: Others
Protein ID: WP_000071008.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EEL44_RS00665137101..137634-534WP_000118351.1GNAT family N-acetyltransferase-
EEL44_RS00670137631..138056-426WP_001882332.1DUF1778 domain-containing protein-
EEL44_RS00675138123..138494-372WP_001164080.1nucleotide pyrophosphohydrolase-
EEL44_RS00680138635..138922-288WP_000426470.1hypothetical protein-
EEL44_RS00685139074..139742-669WP_000043871.1hypothetical protein-
EEL44_RS00690139973..140245+273WP_000246253.1DUF1778 domain-containing protein-
EEL44_RS00695140242..140739+498WP_000982260.1GNAT family N-acetyltransferase-
EEL44_RS00705140941..141093-153WP_001884520.1DUF645 family protein-
EEL44_RS00710141415..141870-456WP_001245327.1GNAT family N-acetyltransferase-
EEL44_RS00715141998..142285-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EEL44_RS00720142275..142526-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
EEL44_RS00725142740..143153-414WP_000049417.1VOC family protein-
EEL44_RS00730143228..143371-144WP_071908341.1DUF3265 domain-containing protein-
EEL44_RS00735143341..143742-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
EEL44_RS00740143742..144434-693WP_001047169.1GNAT family N-acetyltransferase-
EEL44_RS00745144571..144877-307Protein_138CatB-related O-acetyltransferase-
EEL44_RS00750144945..145925+981WP_000019370.1IS5-like element ISVch5 family transposase-
EEL44_RS20945146050..146205-156WP_000751734.1hypothetical protein-
EEL44_RS00755146373..146807-435WP_000256036.1GNAT family N-acetyltransferase-
EEL44_RS00760146944..147258-315WP_000071008.1DNA-binding transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-126763..233717106954
insideIntegron--127139..22687599736
flankIS/Tn--144945..145925980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T113800 WP_000221354.1 NZ_CP033513:c142285-141998 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T113800 NZ_CP033513:c142285-141998 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT113800 WP_001250179.1 NZ_CP033513:c142526-142275 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT113800 NZ_CP033513:c142526-142275 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References