25710

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 74695..75233 Replicon chromosome
Accession NC_016446
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag HJ37_RS14465 Protein ID WP_000802136.1
Coordinates 74695..74994 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag HJ37_RS14470 Protein ID WP_001107719.1
Coordinates 74991..75233 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ37_RS14430 70630..70812 + 183 WP_000923182.1 DUF645 family protein -
HJ37_RS14435 71012..71485 + 474 WP_001161076.1 GrpB family protein -
HJ37_RS19440 71500..71592 + 93 WP_014378730.1 DUF3265 domain-containing protein -
HJ37_RS14440 71634..72260 + 627 WP_000365424.1 LysE family translocator -
HJ37_RS14445 72383..73081 + 699 WP_001890502.1 hypothetical protein -
HJ37_RS19445 73091..73201 + 111 WP_079857360.1 DUF3265 domain-containing protein -
HJ37_RS14455 73779..73958 + 180 WP_001883058.1 DUF645 family protein -
HJ37_RS14460 74172..74567 + 396 WP_000870857.1 DUF3465 domain-containing protein -
HJ37_RS14465 74695..74994 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HJ37_RS14470 74991..75233 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HJ37_RS18950 75462..76040 + 579 WP_000110120.1 hypothetical protein -
HJ37_RS19455 76062..76154 + 93 WP_014164112.1 DUF3265 domain-containing protein -
HJ37_RS14485 76578..77261 + 684 WP_000877436.1 hypothetical protein -
HJ37_RS14490 77475..77741 + 267 WP_000937852.1 hypothetical protein -
HJ37_RS14495 77896..78495 + 600 WP_000429495.1 hypothetical protein -
HJ37_RS14500 78776..79711 + 936 WP_000051985.1 restriction endonuclease -
HJ37_RS19470 79677..79817 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31115..136304 105189
inside Integron catB9 - 36195..135928 99733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T25710 WP_000802136.1 NC_016446:c74994-74695 [Vibrio cholerae O1 str. 2010EL-1786]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T25710 NC_016446:c74994-74695 [Vibrio cholerae O1 str. 2010EL-1786]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT25710 WP_001107719.1 NC_016446:c75233-74991 [Vibrio cholerae O1 str. 2010EL-1786]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT25710 NC_016446:c75233-74991 [Vibrio cholerae O1 str. 2010EL-1786]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References