230647

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 903079..903638 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag LZM82_RS17880 Protein ID WP_000578476.1
Coordinates 903360..903638 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag LZM82_RS17875 Protein ID WP_000381183.1
Coordinates 903079..903363 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZM82_RS17830 (LZM82_17830) 898745..898834 - 90 WP_072606010.1 DUF3265 domain-containing protein -
LZM82_RS17835 (LZM82_17835) 898865..899563 - 699 WP_001890502.1 hypothetical protein -
LZM82_RS17840 (LZM82_17840) 899686..900312 - 627 WP_000365424.1 LysE family translocator -
LZM82_RS17845 (LZM82_17845) 900354..900446 - 93 WP_014378730.1 DUF3265 domain-containing protein -
LZM82_RS17850 (LZM82_17850) 900461..900934 - 474 WP_001161076.1 GrpB family protein -
LZM82_RS17855 (LZM82_17855) 901134..901316 - 183 WP_000923182.1 DUF645 family protein -
LZM82_RS17860 (LZM82_17860) 901377..901514 - 138 WP_001890145.1 hypothetical protein -
LZM82_RS17865 (LZM82_17865) 901708..902304 - 597 WP_000255434.1 hypothetical protein -
LZM82_RS17870 (LZM82_17870) 902369..902830 - 462 WP_001911578.1 lipocalin family protein -
LZM82_RS17875 (LZM82_17875) 903079..903363 + 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LZM82_RS17880 (LZM82_17880) 903360..903638 + 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
LZM82_RS17885 (LZM82_17885) 903789..904202 - 414 WP_000049420.1 VOC family protein -
LZM82_RS17890 (LZM82_17890) 904277..904393 - 117 WP_086010882.1 DUF3265 domain-containing protein -
LZM82_RS17895 (LZM82_17895) 904390..904869 - 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
LZM82_RS17900 (LZM82_17900) 905082..905705 - 624 WP_000247070.1 DUF1349 domain-containing protein -
LZM82_RS17905 (LZM82_17905) 905911..906336 - 426 WP_000415750.1 hypothetical protein -
LZM82_RS17910 (LZM82_17910) 906483..906632 - 150 WP_071908333.1 DUF3265 domain-containing protein -
LZM82_RS17915 (LZM82_17915) 906605..906856 - 252 WP_001890111.1 TIGR03643 family protein -
LZM82_RS17920 (LZM82_17920) 907051..907254 - 204 WP_001911580.1 hypothetical protein -
LZM82_RS17925 (LZM82_17925) 907511..907897 - 387 WP_000703163.1 VOC family protein -
LZM82_RS17930 (LZM82_17930) 908054..908560 - 507 WP_000393074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 835643..943910 108267
inside Integron - - 836019..937068 101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T230647 WP_000578476.1 NZ_CP090400:903360-903638 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T230647 NZ_CP125225:c2375942-2375760 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATAGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACGT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT230647 WP_000381183.1 NZ_CP090400:903079-903363 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT230647 NZ_CP125225:c2375667-2375263 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References