Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 903079..903638 Replicon chromosome
Accession NZ_CP090400
Organism Vibrio cholerae strain PanChol

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag LZM82_RS17880 Protein ID WP_000578476.1
Coordinates 903360..903638 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag LZM82_RS17875 Protein ID WP_000381183.1
Coordinates 903079..903363 (+) Length 95 a.a.

Genomic Context

LZM82_RS17875LZM82_RS17880LZM82_RS17830LZM82_RS17835LZM82_RS17840LZM82_RS17845LZM82_RS17850LZM82_RS17855LZM82_RS17860LZM82_RS17865LZM82_RS17870LZM82_RS17885LZM82_RS17890LZM82_RS17895LZM82_RS17900LZM82_RS17905LZM82_RS17910LZM82_RS17915LZM82_RS17920LZM82_RS17925LZM82_RS17930
Location: 903079..903363 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
Location: 903360..903638 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 898745..898834 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 898865..899563 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 899686..900312 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 900354..900446 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 900461..900934 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 901134..901316 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 901377..901514 (138 bp)
Type: Others
Protein ID: WP_001890145.1
Location: 901708..902304 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 902369..902830 (462 bp)
Type: Others
Protein ID: WP_001911578.1
Location: 903789..904202 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 904277..904393 (117 bp)
Type: Others
Protein ID: WP_086010882.1
Location: 904390..904869 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 905082..905705 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 905911..906336 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 906483..906632 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 906605..906856 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 907051..907254 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 907511..907897 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 908054..908560 (507 bp)
Type: Others
Protein ID: WP_000393074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZM82_RS17830 (LZM82_17830)898745..898834-90WP_072606010.1DUF3265 domain-containing protein-
LZM82_RS17835 (LZM82_17835)898865..899563-699WP_001890502.1hypothetical protein-
LZM82_RS17840 (LZM82_17840)899686..900312-627WP_000365424.1LysE family translocator-
LZM82_RS17845 (LZM82_17845)900354..900446-93WP_014378730.1DUF3265 domain-containing protein-
LZM82_RS17850 (LZM82_17850)900461..900934-474WP_001161076.1GrpB family protein-
LZM82_RS17855 (LZM82_17855)901134..901316-183WP_000923182.1DUF645 family protein-
LZM82_RS17860 (LZM82_17860)901377..901514-138WP_001890145.1hypothetical protein-
LZM82_RS17865 (LZM82_17865)901708..902304-597WP_000255434.1hypothetical protein-
LZM82_RS17870 (LZM82_17870)902369..902830-462WP_001911578.1lipocalin family protein-
LZM82_RS17875 (LZM82_17875)903079..903363+285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
LZM82_RS17880 (LZM82_17880)903360..903638+279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
LZM82_RS17885 (LZM82_17885)903789..904202-414WP_000049420.1VOC family protein-
LZM82_RS17890 (LZM82_17890)904277..904393-117WP_086010882.1DUF3265 domain-containing protein-
LZM82_RS17895 (LZM82_17895)904390..904869-480WP_000009888.1lecithin retinol acyltransferase family protein-
LZM82_RS17900 (LZM82_17900)905082..905705-624WP_000247070.1DUF1349 domain-containing protein-
LZM82_RS17905 (LZM82_17905)905911..906336-426WP_000415750.1hypothetical protein-
LZM82_RS17910 (LZM82_17910)906483..906632-150WP_071908333.1DUF3265 domain-containing protein-
LZM82_RS17915 (LZM82_17915)906605..906856-252WP_001890111.1TIGR03643 family protein-
LZM82_RS17920 (LZM82_17920)907051..907254-204WP_001911580.1hypothetical protein-
LZM82_RS17925 (LZM82_17925)907511..907897-387WP_000703163.1VOC family protein-
LZM82_RS17930 (LZM82_17930)908054..908560-507WP_000393074.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-835643..943910108267
insideIntegron--836019..937068101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T230647 WP_000578476.1 NZ_CP090400:903360-903638 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T230647 NZ_CP125225:c2375942-2375760 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATAGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACGT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT230647 WP_000381183.1 NZ_CP090400:903079-903363 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT230647 NZ_CP125225:c2375667-2375263 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References